Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling

Clinical oncology heavily relies on the use of radiotherapy, which often leads to merely transient responses that are followed by local or distant relapse. The molecular mechanisms explaining radioresistance are largely elusive. Here, we identified a dual role of autophagy in the response of cancer...

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Detalles Bibliográficos
Autores principales: Ko, A, Kanehisa, A, Martins, I, Senovilla, L, Chargari, C, Dugue, D, Mariño, G, Kepp, O, Michaud, M, Perfettini, J-L, Kroemer, G, Deutsch, E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857616/
https://www.ncbi.nlm.nih.gov/pubmed/24037090
http://dx.doi.org/10.1038/cdd.2013.124

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