Ubiquitin-Specific Peptidase 5, a Target Molecule of Vialinin A, Is a Key Molecule of TNF-α Production in RBL-2H3 Cells

Tumor necrosis factor alpha (TNF-α), a central mediator of the inflammatory response, is released from basophilic cells and other cells in response to a variety of proinflammatory stimuli. Vialinin A is a potent inhibitor of TNF-α production and is released from RBL-2H3 cells. Ubiquitin-specific pep...

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Detalles Bibliográficos
Autores principales: Yoshioka, Yasukiyo, Ye, Yue Qi, Okada, Kiyoshi, Taniguchi, Kayoko, Yoshida, Ayaka, Sugaya, Kouichi, Onose, Jun-ichi, Koshino, Hiroyuki, Takahashi, Shunya, Yajima, Arata, Yajima, Shunsuke, Abe, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857809/
https://www.ncbi.nlm.nih.gov/pubmed/24349023
http://dx.doi.org/10.1371/journal.pone.0080931
Descripción
Sumario:Tumor necrosis factor alpha (TNF-α), a central mediator of the inflammatory response, is released from basophilic cells and other cells in response to a variety of proinflammatory stimuli. Vialinin A is a potent inhibitor of TNF-α production and is released from RBL-2H3 cells. Ubiquitin-specific peptidase 5 (USP5), a deubiquitinating enzyme, was identified as a target molecule of vialinin A and its enzymatic activity was inhibited by vialinin A. Here we report production of TNF-α is decreased in USP5 siRNA-knockdown RBL-2H3 cells, compared with control cells. The finding of the present study strongly suggests that USP5 is one of the essential molecules for the production of TNF-α in RBL-2H3.

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