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Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism

Background. Vest chest physiotherapy (VCPT) enhances airway clearance in cystic fibrosis (CF) by an unknown mechanism. Because cilia are sensitive to nitric oxide (NO), we hypothesized that VCPT enhances clearance by changing NO metabolism. Methods. Both normal subjects and stable CF subjects had pr...

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Autores principales: Sisson, Joseph H., Wyatt, Todd A., Pavlik, Jacqueline A., Sarna, Pawanjit S., Murphy, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857909/
https://www.ncbi.nlm.nih.gov/pubmed/24349778
http://dx.doi.org/10.1155/2013/291375
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author Sisson, Joseph H.
Wyatt, Todd A.
Pavlik, Jacqueline A.
Sarna, Pawanjit S.
Murphy, Peter J.
author_facet Sisson, Joseph H.
Wyatt, Todd A.
Pavlik, Jacqueline A.
Sarna, Pawanjit S.
Murphy, Peter J.
author_sort Sisson, Joseph H.
collection PubMed
description Background. Vest chest physiotherapy (VCPT) enhances airway clearance in cystic fibrosis (CF) by an unknown mechanism. Because cilia are sensitive to nitric oxide (NO), we hypothesized that VCPT enhances clearance by changing NO metabolism. Methods. Both normal subjects and stable CF subjects had pre- and post-VCPT airway clearance assessed using nasal saccharin transit time (NSTT) followed by a collection of exhaled breath condensate (EBC) analyzed for NO metabolites (NO(x)). Results. VCPT shorted NSTT by 35% in normal and stable CF subjects with no difference observed between the groups. EBC NO(x) concentrations decreased 68% in control subjects after VCPT (before = 115 ± 32 μM versus after = 37 ± 17 μM; P < 0.002). CF subjects had a trend toward lower EBC NO(x). Conclusion. We found an association between VCPT-stimulated clearance and exhaled NO(x) levels in human subjects. We speculate that VCPT stimulates clearance via increased NO metabolism.
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spelling pubmed-38579092013-12-17 Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism Sisson, Joseph H. Wyatt, Todd A. Pavlik, Jacqueline A. Sarna, Pawanjit S. Murphy, Peter J. Pulm Med Research Article Background. Vest chest physiotherapy (VCPT) enhances airway clearance in cystic fibrosis (CF) by an unknown mechanism. Because cilia are sensitive to nitric oxide (NO), we hypothesized that VCPT enhances clearance by changing NO metabolism. Methods. Both normal subjects and stable CF subjects had pre- and post-VCPT airway clearance assessed using nasal saccharin transit time (NSTT) followed by a collection of exhaled breath condensate (EBC) analyzed for NO metabolites (NO(x)). Results. VCPT shorted NSTT by 35% in normal and stable CF subjects with no difference observed between the groups. EBC NO(x) concentrations decreased 68% in control subjects after VCPT (before = 115 ± 32 μM versus after = 37 ± 17 μM; P < 0.002). CF subjects had a trend toward lower EBC NO(x). Conclusion. We found an association between VCPT-stimulated clearance and exhaled NO(x) levels in human subjects. We speculate that VCPT stimulates clearance via increased NO metabolism. Hindawi Publishing Corporation 2013 2013-11-21 /pmc/articles/PMC3857909/ /pubmed/24349778 http://dx.doi.org/10.1155/2013/291375 Text en Copyright © 2013 Joseph H. Sisson et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sisson, Joseph H.
Wyatt, Todd A.
Pavlik, Jacqueline A.
Sarna, Pawanjit S.
Murphy, Peter J.
Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism
title Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism
title_full Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism
title_fullStr Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism
title_full_unstemmed Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism
title_short Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism
title_sort vest chest physiotherapy airway clearance is associated with nitric oxide metabolism
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857909/
https://www.ncbi.nlm.nih.gov/pubmed/24349778
http://dx.doi.org/10.1155/2013/291375
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