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Study on Incompatibility of Traditional Chinese Medicine: Evidence from Formula Network, Chemical Space, and Metabolism Room
A traditional Chinese medicine (TCM) formula network including 362 TCM formulas was built by using complex network methodologies. The properties of this network were analyzed including network diameter, average distance, clustering coefficient, and average degree. Meanwhile, we built a TCM chemical...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858019/ https://www.ncbi.nlm.nih.gov/pubmed/24369478 http://dx.doi.org/10.1155/2013/352145 |
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author | Long, Wei Zhang, Xiao-Dong Wu, Hong-Ying Jin, Jin Yu, Guang-Yun He, Xin Wang, Hao Shen, Xiu Zhou, Ze-Wei Liu, Pei-Xun Fan, Sai-Jun |
author_facet | Long, Wei Zhang, Xiao-Dong Wu, Hong-Ying Jin, Jin Yu, Guang-Yun He, Xin Wang, Hao Shen, Xiu Zhou, Ze-Wei Liu, Pei-Xun Fan, Sai-Jun |
author_sort | Long, Wei |
collection | PubMed |
description | A traditional Chinese medicine (TCM) formula network including 362 TCM formulas was built by using complex network methodologies. The properties of this network were analyzed including network diameter, average distance, clustering coefficient, and average degree. Meanwhile, we built a TCM chemical space and a TCM metabolism room under the theory of chemical space. The properties of chemical space and metabolism room were calculated and analyzed. The properties of the medicine pairs in “eighteen antagonisms and nineteen mutual inhibitors,” an ancient rule for TCM incompatibility, were studied based on the TCM formula network, chemical space, and metabolism room. The results showed that the properties of these incompatible medicine pairs are different from those of the other TCM based on the analysis of the TCM formula network, chemical space, and metabolism room. The lines of evidence derived from our work demonstrated that the ancient rule of TCM incompatibility, “eighteen antagonisms and nineteen mutual inhibitors,” is probably scientifically based. |
format | Online Article Text |
id | pubmed-3858019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38580192013-12-25 Study on Incompatibility of Traditional Chinese Medicine: Evidence from Formula Network, Chemical Space, and Metabolism Room Long, Wei Zhang, Xiao-Dong Wu, Hong-Ying Jin, Jin Yu, Guang-Yun He, Xin Wang, Hao Shen, Xiu Zhou, Ze-Wei Liu, Pei-Xun Fan, Sai-Jun Evid Based Complement Alternat Med Research Article A traditional Chinese medicine (TCM) formula network including 362 TCM formulas was built by using complex network methodologies. The properties of this network were analyzed including network diameter, average distance, clustering coefficient, and average degree. Meanwhile, we built a TCM chemical space and a TCM metabolism room under the theory of chemical space. The properties of chemical space and metabolism room were calculated and analyzed. The properties of the medicine pairs in “eighteen antagonisms and nineteen mutual inhibitors,” an ancient rule for TCM incompatibility, were studied based on the TCM formula network, chemical space, and metabolism room. The results showed that the properties of these incompatible medicine pairs are different from those of the other TCM based on the analysis of the TCM formula network, chemical space, and metabolism room. The lines of evidence derived from our work demonstrated that the ancient rule of TCM incompatibility, “eighteen antagonisms and nineteen mutual inhibitors,” is probably scientifically based. Hindawi Publishing Corporation 2013 2013-11-24 /pmc/articles/PMC3858019/ /pubmed/24369478 http://dx.doi.org/10.1155/2013/352145 Text en Copyright © 2013 Wei Long et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Long, Wei Zhang, Xiao-Dong Wu, Hong-Ying Jin, Jin Yu, Guang-Yun He, Xin Wang, Hao Shen, Xiu Zhou, Ze-Wei Liu, Pei-Xun Fan, Sai-Jun Study on Incompatibility of Traditional Chinese Medicine: Evidence from Formula Network, Chemical Space, and Metabolism Room |
title | Study on Incompatibility of Traditional Chinese Medicine: Evidence from Formula Network, Chemical Space, and Metabolism Room |
title_full | Study on Incompatibility of Traditional Chinese Medicine: Evidence from Formula Network, Chemical Space, and Metabolism Room |
title_fullStr | Study on Incompatibility of Traditional Chinese Medicine: Evidence from Formula Network, Chemical Space, and Metabolism Room |
title_full_unstemmed | Study on Incompatibility of Traditional Chinese Medicine: Evidence from Formula Network, Chemical Space, and Metabolism Room |
title_short | Study on Incompatibility of Traditional Chinese Medicine: Evidence from Formula Network, Chemical Space, and Metabolism Room |
title_sort | study on incompatibility of traditional chinese medicine: evidence from formula network, chemical space, and metabolism room |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858019/ https://www.ncbi.nlm.nih.gov/pubmed/24369478 http://dx.doi.org/10.1155/2013/352145 |
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