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Life-Stage-, Sex-, and Dose-Dependent Dietary Toxicokinetics and Relationship to Toxicity of 2,4-Dichlorophenoxyacetic Acid (2,4-D) in Rats: Implications for Toxicity Test Dose Selection, Design, and Interpretation

Life-stage-dependent toxicity and dose-dependent toxicokinetics (TK) were evaluated in Sprague Dawley rats following dietary exposure to 2,4-dichlorophenoxyacetic acid (2,4-D). 2,4-D renal clearance is impacted by dose-dependent saturation of the renal organic anion transporter; thus, this study foc...

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Detalles Bibliográficos
Autores principales:	Saghir, Shakil A., Marty, Mary S., Zablotny, Carol L., Passage, Julie K., Perala, Adam W., Neal, Barbara H., Hammond, Larry, Bus, James S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858196/ https://www.ncbi.nlm.nih.gov/pubmed/24105888 http://dx.doi.org/10.1093/toxsci/kft212

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