Effectors of Epidermal Growth Factor Receptor Pathway: The Genetic Profiling of KRAS, BRAF, PIK3CA, NRAS Mutations in Colorectal Cancer Characteristics and Personalized Medicine

Mutations in KRAS oncogene are recognized biomarkers that predict lack of response to anti- epidermal growth factor receptor (EGFR) antibody therapies. However, some patients with KRAS wild-type tumors still do not respond, so other downstream mutations in BRAF, PIK3CA and NRAS should be investigate...

Descripción completa

Detalles Bibliográficos
Autores principales: Shen, Yinchen, Wang, Jianfei, Han, Xiaohong, Yang, Hongying, Wang, Shuai, Lin, Dongmei, Shi, Yuankai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858242/
https://www.ncbi.nlm.nih.gov/pubmed/24339949
http://dx.doi.org/10.1371/journal.pone.0081628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858242/
https://www.ncbi.nlm.nih.gov/pubmed/24339949
http://dx.doi.org/10.1371/journal.pone.0081628

Ejemplares similares