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Effectors of Epidermal Growth Factor Receptor Pathway: The Genetic Profiling of KRAS, BRAF, PIK3CA, NRAS Mutations in Colorectal Cancer Characteristics and Personalized Medicine

Mutations in KRAS oncogene are recognized biomarkers that predict lack of response to anti- epidermal growth factor receptor (EGFR) antibody therapies. However, some patients with KRAS wild-type tumors still do not respond, so other downstream mutations in BRAF, PIK3CA and NRAS should be investigate...

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Detalles Bibliográficos
Autores principales:	Shen, Yinchen, Wang, Jianfei, Han, Xiaohong, Yang, Hongying, Wang, Shuai, Lin, Dongmei, Shi, Yuankai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858242/ https://www.ncbi.nlm.nih.gov/pubmed/24339949 http://dx.doi.org/10.1371/journal.pone.0081628

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