Probing the Effect of the Non-Active-Site Mutation Y229W in New Delhi Metallo-β-lactamase-1 by Site-Directed Mutagenesis, Kinetic Studies, and Molecular Dynamics Simulations

New Delhi metallo-β-lactmase-1 (NDM-1) has attracted extensive attention for its high catalytic activities of hydrolyzing almost all β-lactam antibiotics. NDM-1 shows relatively higher similarity to subclass B1 metallo-β-lactmases (MβLs), but its residue at position 229 is identical to that of B2/B3...

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Detalles Bibliográficos
Autores principales: Chen, Jiao, Chen, Hui, Shi, Yun, Hu, Feng, Lao, Xingzhen, Gao, Xiangdong, Zheng, Heng, Yao, Wenbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858288/
https://www.ncbi.nlm.nih.gov/pubmed/24339993
http://dx.doi.org/10.1371/journal.pone.0082080

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