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Pharmacophore Modeling and Virtual Screening for the Discovery of New type 4 cAMP Phosphodiesterase (PDE4) Inhibitors

Type 4 cAMP phosphodiesterase (PDE4) inhibitors show a broad spectrum of anti-inflammatory effects in almost all kinds of inflamed cells, by an increase in cAMP levels which is a pivotal second messenger responsible for various biological processes. These inhibitors are now considered as the potenti...

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Detalles Bibliográficos
Autores principales:	Niu, Miaomiao, Dong, Fenggong, Tang, Shi, Fida, Guissi, Qin, Jingyi, Qiu, Jiadan, Liu, Kangbo, Gao, Weidong, Gu, Yueqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858292/ https://www.ncbi.nlm.nih.gov/pubmed/24340020 http://dx.doi.org/10.1371/journal.pone.0082360

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