Genetic Interaction between Mutations in c-Myb and the KIX Domains of CBP and p300 Affects Multiple Blood Cell Lineages and Influences Both Gene Activation and Repression

Adult blood cell production or definitive hematopoiesis requires the transcription factor c-Myb. The closely related KAT3 histone acetyltransferases CBP (CREBBP) and p300 (EP300) bind c-Myb through their KIX domains and mice homozygous for a p300 KIX domain mutation exhibit multiple blood defects. P...

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Detalles Bibliográficos
Autores principales: Kasper, Lawryn H., Fukuyama, Tomofusa, Lerach, Stephanie, Chang, Yunchao, Xu, Wu, Wu, Song, Boyd, Kelli L., Brindle, Paul K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858336/
https://www.ncbi.nlm.nih.gov/pubmed/24340053
http://dx.doi.org/10.1371/journal.pone.0082684

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