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Inter-Subunit Interactions across the Upper Voltage Sensing-Pore Domain Interface Contribute to the Concerted Pore Opening Transition of Kv Channels

The tight electro-mechanical coupling between the voltage-sensing and pore domains of Kv channels lies at the heart of their fundamental roles in electrical signaling. Structural data have identified two voltage sensor pore inter-domain interaction surfaces, thus providing a framework to explain the...

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Detalles Bibliográficos
Autores principales: Shem-Ad, Tzilhav, Irit, Orr, Yifrach, Ofer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858418/
https://www.ncbi.nlm.nih.gov/pubmed/24340010
http://dx.doi.org/10.1371/journal.pone.0082253