The Panhandle Formed by Influenza A and C Virus NS Non-Coding Regions Determines NS Segment Expression

Exchange of the extremities of the NS segment of type A and C influenza viruses in reverse genetics systems was used to assess their putative role in type specificity. Restoration of each specific proximal panhandle was mandatory to allow the rescue of viruses with heterotypic extremities. Moreover,...

Descripción completa

Detalles Bibliográficos
Autores principales: Crescenzo-Chaigne, Bernadette, Barbezange, Cyril, van der Werf, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858493/
https://www.ncbi.nlm.nih.gov/pubmed/24348921
http://dx.doi.org/10.1371/journal.pone.0081550
Descripción
Sumario:Exchange of the extremities of the NS segment of type A and C influenza viruses in reverse genetics systems was used to assess their putative role in type specificity. Restoration of each specific proximal panhandle was mandatory to allow the rescue of viruses with heterotypic extremities. Moreover, the transcription level of the modified segment seemed to be directly affected by the distal panhandle strength.

Ejemplares similares