The Panhandle Formed by Influenza A and C Virus NS Non-Coding Regions Determines NS Segment Expression

Exchange of the extremities of the NS segment of type A and C influenza viruses in reverse genetics systems was used to assess their putative role in type specificity. Restoration of each specific proximal panhandle was mandatory to allow the rescue of viruses with heterotypic extremities. Moreover,...

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Autores principales: Crescenzo-Chaigne, Bernadette, Barbezange, Cyril, van der Werf, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858493/
https://www.ncbi.nlm.nih.gov/pubmed/24348921
http://dx.doi.org/10.1371/journal.pone.0081550
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author Crescenzo-Chaigne, Bernadette
Barbezange, Cyril
van der Werf, Sylvie
author_facet Crescenzo-Chaigne, Bernadette
Barbezange, Cyril
van der Werf, Sylvie
author_sort Crescenzo-Chaigne, Bernadette
collection PubMed
description Exchange of the extremities of the NS segment of type A and C influenza viruses in reverse genetics systems was used to assess their putative role in type specificity. Restoration of each specific proximal panhandle was mandatory to allow the rescue of viruses with heterotypic extremities. Moreover, the transcription level of the modified segment seemed to be directly affected by the distal panhandle strength.
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spelling pubmed-38584932013-12-12 The Panhandle Formed by Influenza A and C Virus NS Non-Coding Regions Determines NS Segment Expression Crescenzo-Chaigne, Bernadette Barbezange, Cyril van der Werf, Sylvie PLoS One Research Article Exchange of the extremities of the NS segment of type A and C influenza viruses in reverse genetics systems was used to assess their putative role in type specificity. Restoration of each specific proximal panhandle was mandatory to allow the rescue of viruses with heterotypic extremities. Moreover, the transcription level of the modified segment seemed to be directly affected by the distal panhandle strength. Public Library of Science 2013-11-21 /pmc/articles/PMC3858493/ /pubmed/24348921 http://dx.doi.org/10.1371/journal.pone.0081550 Text en © 2013 Crescenzo-Chaigne et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Crescenzo-Chaigne, Bernadette
Barbezange, Cyril
van der Werf, Sylvie
The Panhandle Formed by Influenza A and C Virus NS Non-Coding Regions Determines NS Segment Expression
title The Panhandle Formed by Influenza A and C Virus NS Non-Coding Regions Determines NS Segment Expression
title_full The Panhandle Formed by Influenza A and C Virus NS Non-Coding Regions Determines NS Segment Expression
title_fullStr The Panhandle Formed by Influenza A and C Virus NS Non-Coding Regions Determines NS Segment Expression
title_full_unstemmed The Panhandle Formed by Influenza A and C Virus NS Non-Coding Regions Determines NS Segment Expression
title_short The Panhandle Formed by Influenza A and C Virus NS Non-Coding Regions Determines NS Segment Expression
title_sort panhandle formed by influenza a and c virus ns non-coding regions determines ns segment expression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858493/
https://www.ncbi.nlm.nih.gov/pubmed/24348921
http://dx.doi.org/10.1371/journal.pone.0081550
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