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Small-molecule targeting of translation initiation for cancer therapy

Translation initiation plays a critical role in the regulation of cell growth and tumorigenesis. We report here that inhibiting translation initiation through induction of eIF2α phosphorylation by small-molecular-weight compounds restricts the availability of the eIF2·GTP·Met-tRNA(i) ternary complex...

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Detalles Bibliográficos
Autores principales:	Aktas, Bertal H., Qiao, Yuan, Ozdelen, Esra, Schubert, Roland, Sevinc, Sema, Harbinski, Fred, Grubissich, Luciano, Singer, Samuel, Halperin, Jose A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2013
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858549/ https://www.ncbi.nlm.nih.gov/pubmed/24091475

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