Cargando…
Maternal Protein Restriction in the Rat Inhibits Placental Insulin, mTOR, and STAT3 Signaling and Down-Regulates Placental Amino Acid Transporters
The mechanisms underlying reduced fetal growth in response to maternal protein restriction are not well established. Maternal levels of insulin, IGF-I, and leptin are decreased in rats fed a low protein (LP) diet. Because these hormones stimulate placental amino acid transporters in vitro, we hypoth...
Autores principales: | Rosario, Fredrick J., Jansson, Nina, Kanai, Yoshikatsu, Prasad, Puttur D., Powell, Theresa L., Jansson, Thomas |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Endocrine Society
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858644/ https://www.ncbi.nlm.nih.gov/pubmed/21285325 http://dx.doi.org/10.1210/en.2010-1153 |
Ejemplares similares
-
Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice
por: Rosario, Fredrick J., et al.
Publicado: (2017) -
Down-Regulation of Placental Transport of Amino Acids Precedes the Development of Intrauterine Growth Restriction in Maternal Nutrient Restricted Baboons
por: Pantham, Priyadarshini, et al.
Publicado: (2016) -
Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight
por: Dimasuay, Kris Genelyn, et al.
Publicado: (2017) -
Diet‐induced obesity in mice reduces placental efficiency and inhibits placental mTOR signaling
por: Lager, Susanne, et al.
Publicado: (2014) -
Placental Remote Control of Fetal Metabolism: Trophoblast mTOR Signaling Regulates Liver IGFBP-1 Phosphorylation and IGF-1 Bioavailability
por: Rosario, Fredrick J., et al.
Publicado: (2023)