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Evaluation of VEGF-C and Tumor Markers in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis

A total of 87 patients were enrolled and bronchoalveolar lavage fluid (BALF) samples were obtained from all subjects. A significant difference was found in BALF VEGF-C level between patients with squamous cell carcinoma and benign diseases (P = 0.043). In addition, the concentration of NSE in BALF f...

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Autores principales: Cao, Chao, Chen, Zhong-Bo, Sun, Shi-Fang, Yu, Yi-Ming, Ding, Qun-Li, Deng, Zai-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858788/
https://www.ncbi.nlm.nih.gov/pubmed/24326979
http://dx.doi.org/10.1038/srep03473
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author Cao, Chao
Chen, Zhong-Bo
Sun, Shi-Fang
Yu, Yi-Ming
Ding, Qun-Li
Deng, Zai-Chun
author_facet Cao, Chao
Chen, Zhong-Bo
Sun, Shi-Fang
Yu, Yi-Ming
Ding, Qun-Li
Deng, Zai-Chun
author_sort Cao, Chao
collection PubMed
description A total of 87 patients were enrolled and bronchoalveolar lavage fluid (BALF) samples were obtained from all subjects. A significant difference was found in BALF VEGF-C level between patients with squamous cell carcinoma and benign diseases (P = 0.043). In addition, the concentration of NSE in BALF form the malignant group was significantly higher compared with that of the benign groups (P = 0.018). However, no statistical difference was observed in BALF CEA (P = 0.375) or CYFRA21-1 (P = 0.838) between lung cancer patients and nonmalignant controls. With a cut-off value of 2.06 ng/ml, NSE had a sensitivity of 72.9%, a specificity of 69.2%, respectively, in predicting the malignant nature of pulmonary mass. Our study observed that the level of VEGF-C was increased in BALF of patients with squamous cell carcinoma. Moreover, we found that NSE was significantly higher in BALF of lung cancer patients than in benign diseases.
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spelling pubmed-38587882013-12-11 Evaluation of VEGF-C and Tumor Markers in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis Cao, Chao Chen, Zhong-Bo Sun, Shi-Fang Yu, Yi-Ming Ding, Qun-Li Deng, Zai-Chun Sci Rep Article A total of 87 patients were enrolled and bronchoalveolar lavage fluid (BALF) samples were obtained from all subjects. A significant difference was found in BALF VEGF-C level between patients with squamous cell carcinoma and benign diseases (P = 0.043). In addition, the concentration of NSE in BALF form the malignant group was significantly higher compared with that of the benign groups (P = 0.018). However, no statistical difference was observed in BALF CEA (P = 0.375) or CYFRA21-1 (P = 0.838) between lung cancer patients and nonmalignant controls. With a cut-off value of 2.06 ng/ml, NSE had a sensitivity of 72.9%, a specificity of 69.2%, respectively, in predicting the malignant nature of pulmonary mass. Our study observed that the level of VEGF-C was increased in BALF of patients with squamous cell carcinoma. Moreover, we found that NSE was significantly higher in BALF of lung cancer patients than in benign diseases. Nature Publishing Group 2013-12-11 /pmc/articles/PMC3858788/ /pubmed/24326979 http://dx.doi.org/10.1038/srep03473 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Article
Cao, Chao
Chen, Zhong-Bo
Sun, Shi-Fang
Yu, Yi-Ming
Ding, Qun-Li
Deng, Zai-Chun
Evaluation of VEGF-C and Tumor Markers in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis
title Evaluation of VEGF-C and Tumor Markers in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis
title_full Evaluation of VEGF-C and Tumor Markers in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis
title_fullStr Evaluation of VEGF-C and Tumor Markers in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis
title_full_unstemmed Evaluation of VEGF-C and Tumor Markers in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis
title_short Evaluation of VEGF-C and Tumor Markers in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis
title_sort evaluation of vegf-c and tumor markers in bronchoalveolar lavage fluid for lung cancer diagnosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858788/
https://www.ncbi.nlm.nih.gov/pubmed/24326979
http://dx.doi.org/10.1038/srep03473
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