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Evaluation of VEGF-C and Tumor Markers in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis
A total of 87 patients were enrolled and bronchoalveolar lavage fluid (BALF) samples were obtained from all subjects. A significant difference was found in BALF VEGF-C level between patients with squamous cell carcinoma and benign diseases (P = 0.043). In addition, the concentration of NSE in BALF f...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858788/ https://www.ncbi.nlm.nih.gov/pubmed/24326979 http://dx.doi.org/10.1038/srep03473 |
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author | Cao, Chao Chen, Zhong-Bo Sun, Shi-Fang Yu, Yi-Ming Ding, Qun-Li Deng, Zai-Chun |
author_facet | Cao, Chao Chen, Zhong-Bo Sun, Shi-Fang Yu, Yi-Ming Ding, Qun-Li Deng, Zai-Chun |
author_sort | Cao, Chao |
collection | PubMed |
description | A total of 87 patients were enrolled and bronchoalveolar lavage fluid (BALF) samples were obtained from all subjects. A significant difference was found in BALF VEGF-C level between patients with squamous cell carcinoma and benign diseases (P = 0.043). In addition, the concentration of NSE in BALF form the malignant group was significantly higher compared with that of the benign groups (P = 0.018). However, no statistical difference was observed in BALF CEA (P = 0.375) or CYFRA21-1 (P = 0.838) between lung cancer patients and nonmalignant controls. With a cut-off value of 2.06 ng/ml, NSE had a sensitivity of 72.9%, a specificity of 69.2%, respectively, in predicting the malignant nature of pulmonary mass. Our study observed that the level of VEGF-C was increased in BALF of patients with squamous cell carcinoma. Moreover, we found that NSE was significantly higher in BALF of lung cancer patients than in benign diseases. |
format | Online Article Text |
id | pubmed-3858788 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-38587882013-12-11 Evaluation of VEGF-C and Tumor Markers in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis Cao, Chao Chen, Zhong-Bo Sun, Shi-Fang Yu, Yi-Ming Ding, Qun-Li Deng, Zai-Chun Sci Rep Article A total of 87 patients were enrolled and bronchoalveolar lavage fluid (BALF) samples were obtained from all subjects. A significant difference was found in BALF VEGF-C level between patients with squamous cell carcinoma and benign diseases (P = 0.043). In addition, the concentration of NSE in BALF form the malignant group was significantly higher compared with that of the benign groups (P = 0.018). However, no statistical difference was observed in BALF CEA (P = 0.375) or CYFRA21-1 (P = 0.838) between lung cancer patients and nonmalignant controls. With a cut-off value of 2.06 ng/ml, NSE had a sensitivity of 72.9%, a specificity of 69.2%, respectively, in predicting the malignant nature of pulmonary mass. Our study observed that the level of VEGF-C was increased in BALF of patients with squamous cell carcinoma. Moreover, we found that NSE was significantly higher in BALF of lung cancer patients than in benign diseases. Nature Publishing Group 2013-12-11 /pmc/articles/PMC3858788/ /pubmed/24326979 http://dx.doi.org/10.1038/srep03473 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Article Cao, Chao Chen, Zhong-Bo Sun, Shi-Fang Yu, Yi-Ming Ding, Qun-Li Deng, Zai-Chun Evaluation of VEGF-C and Tumor Markers in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis |
title | Evaluation of VEGF-C and Tumor Markers in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis |
title_full | Evaluation of VEGF-C and Tumor Markers in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis |
title_fullStr | Evaluation of VEGF-C and Tumor Markers in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis |
title_full_unstemmed | Evaluation of VEGF-C and Tumor Markers in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis |
title_short | Evaluation of VEGF-C and Tumor Markers in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis |
title_sort | evaluation of vegf-c and tumor markers in bronchoalveolar lavage fluid for lung cancer diagnosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858788/ https://www.ncbi.nlm.nih.gov/pubmed/24326979 http://dx.doi.org/10.1038/srep03473 |
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