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Manipulating the pH response of 2,3-diaminopropionic acid rich peptides to mediate highly effective gene silencing with low-toxicity()
Cationic amphipathic pH responsive peptides possess high in vitro and in vivo nucleic acid delivery capabilities and function by forming a non-covalent complex with cargo, protecting it from nucleases, facilitating uptake via endocytosis and responding to endosomal acidification by being released fr...
Autores principales: | Abbate, Vincenzo, Liang, Wanling, Patel, Jayneil, Lan, Yun, Capriotti, Luigi, Iacobucci, Valentina, Bui, Tam T., Chaudhuri, Poulami, Kudsiova, Laila, Vermeer, Louic S., Chan, Patrick F.L., Kong, Xiaole, Drake, Alex F., Lam, Jenny K.W., Bansal, Sukhvinder S., Mason, A. James |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science Publishers
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858832/ https://www.ncbi.nlm.nih.gov/pubmed/24144917 http://dx.doi.org/10.1016/j.jconrel.2013.09.033 |
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