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Acylated and Desacylated Ghrelin, Preptin, Leptin, and Nesfatin-1 Peptide Changes Related to the Body Mass Index
This study examines the levels of acylated and desacylated ghrelin, preptin, leptin, and nesfatin-1 peptide changes related to the body mass index (BMI). The subjects were allocated to 5 groups depending on their BMIs as follows: Group I (BMI <18.5 kg/m(2)); Group II (BMI 18.5–24.9 kg/m(2)); Grou...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858877/ https://www.ncbi.nlm.nih.gov/pubmed/24371438 http://dx.doi.org/10.1155/2013/236085 |
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author | Ozkan, Yusuf Timurkan, Esra Suay Aydin, Suleyman Sahin, İbrahim Timurkan, Mustafa Citil, Cihan Kalayci, Mehmet Yilmaz, Musa Aksoy, Aziz Catak, Zekiye |
author_facet | Ozkan, Yusuf Timurkan, Esra Suay Aydin, Suleyman Sahin, İbrahim Timurkan, Mustafa Citil, Cihan Kalayci, Mehmet Yilmaz, Musa Aksoy, Aziz Catak, Zekiye |
author_sort | Ozkan, Yusuf |
collection | PubMed |
description | This study examines the levels of acylated and desacylated ghrelin, preptin, leptin, and nesfatin-1 peptide changes related to the body mass index (BMI). The subjects were allocated to 5 groups depending on their BMIs as follows: Group I (BMI <18.5 kg/m(2)); Group II (BMI 18.5–24.9 kg/m(2)); Group III (BMI 25–29.9 kg/m(2)); Group IV (BMI 30–39.9 kg/m(2)); Group V (BMI >40 kg/m(2)). Serum acylated and desacylated ghrelin, preptin, and leptin levels were measured by the enzyme-linked immunosorbent assay (ELISA) and nesfatin-1 was measured by the enzyme immunoassay (EIA). Desacylated ghrelin levels showed a gradual and statistically significant drop from Group I to Group V, while preptin and leptin levels exhibited a gradual and significant increase from Group I to Group IV. Serum nesfatin-1 levels gradually, but not significantly, increased from Group I to Group III and showed a significant decrease in Groups IV and V. In conclusion, leptin, preptin, and acylated ghrelin (AG) levels increased with higher BMI, whereas desacylated ghrelin (DAG) decreased and nesfatin-1 showed no clear relationship to BMI. |
format | Online Article Text |
id | pubmed-3858877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38588772013-12-26 Acylated and Desacylated Ghrelin, Preptin, Leptin, and Nesfatin-1 Peptide Changes Related to the Body Mass Index Ozkan, Yusuf Timurkan, Esra Suay Aydin, Suleyman Sahin, İbrahim Timurkan, Mustafa Citil, Cihan Kalayci, Mehmet Yilmaz, Musa Aksoy, Aziz Catak, Zekiye Int J Endocrinol Research Article This study examines the levels of acylated and desacylated ghrelin, preptin, leptin, and nesfatin-1 peptide changes related to the body mass index (BMI). The subjects were allocated to 5 groups depending on their BMIs as follows: Group I (BMI <18.5 kg/m(2)); Group II (BMI 18.5–24.9 kg/m(2)); Group III (BMI 25–29.9 kg/m(2)); Group IV (BMI 30–39.9 kg/m(2)); Group V (BMI >40 kg/m(2)). Serum acylated and desacylated ghrelin, preptin, and leptin levels were measured by the enzyme-linked immunosorbent assay (ELISA) and nesfatin-1 was measured by the enzyme immunoassay (EIA). Desacylated ghrelin levels showed a gradual and statistically significant drop from Group I to Group V, while preptin and leptin levels exhibited a gradual and significant increase from Group I to Group IV. Serum nesfatin-1 levels gradually, but not significantly, increased from Group I to Group III and showed a significant decrease in Groups IV and V. In conclusion, leptin, preptin, and acylated ghrelin (AG) levels increased with higher BMI, whereas desacylated ghrelin (DAG) decreased and nesfatin-1 showed no clear relationship to BMI. Hindawi Publishing Corporation 2013 2013-11-25 /pmc/articles/PMC3858877/ /pubmed/24371438 http://dx.doi.org/10.1155/2013/236085 Text en Copyright © 2013 Yusuf Ozkan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ozkan, Yusuf Timurkan, Esra Suay Aydin, Suleyman Sahin, İbrahim Timurkan, Mustafa Citil, Cihan Kalayci, Mehmet Yilmaz, Musa Aksoy, Aziz Catak, Zekiye Acylated and Desacylated Ghrelin, Preptin, Leptin, and Nesfatin-1 Peptide Changes Related to the Body Mass Index |
title | Acylated and Desacylated Ghrelin, Preptin, Leptin, and Nesfatin-1 Peptide Changes Related to the Body Mass Index |
title_full | Acylated and Desacylated Ghrelin, Preptin, Leptin, and Nesfatin-1 Peptide Changes Related to the Body Mass Index |
title_fullStr | Acylated and Desacylated Ghrelin, Preptin, Leptin, and Nesfatin-1 Peptide Changes Related to the Body Mass Index |
title_full_unstemmed | Acylated and Desacylated Ghrelin, Preptin, Leptin, and Nesfatin-1 Peptide Changes Related to the Body Mass Index |
title_short | Acylated and Desacylated Ghrelin, Preptin, Leptin, and Nesfatin-1 Peptide Changes Related to the Body Mass Index |
title_sort | acylated and desacylated ghrelin, preptin, leptin, and nesfatin-1 peptide changes related to the body mass index |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858877/ https://www.ncbi.nlm.nih.gov/pubmed/24371438 http://dx.doi.org/10.1155/2013/236085 |
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