Cargando…

Revisiting the Prominent Anti-Tumoral Potential of Pre-mNK Cells

Interferon-producing killer dendritic cells (IKDC) were first described for their outstanding anti-tumoral properties. The “IKDC” terminology implied the description of a novel DC subset and initiated a debate on their cellular lineage origin. This debate shifted the focus away from their notable an...

Descripción completa

Detalles Bibliográficos
Autores principales: Guimont-Desrochers, Fanny, Lesage, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858890/
https://www.ncbi.nlm.nih.gov/pubmed/24376447
http://dx.doi.org/10.3389/fimmu.2013.00446
_version_ 1782295344079437824
author Guimont-Desrochers, Fanny
Lesage, Sylvie
author_facet Guimont-Desrochers, Fanny
Lesage, Sylvie
author_sort Guimont-Desrochers, Fanny
collection PubMed
description Interferon-producing killer dendritic cells (IKDC) were first described for their outstanding anti-tumoral properties. The “IKDC” terminology implied the description of a novel DC subset and initiated a debate on their cellular lineage origin. This debate shifted the focus away from their notable anti-tumoral potential. IKDC were recently redefined as precursors to mature NK (mNK) cells and consequently renamed pre-mNK cells. Importantly, a putative human equivalent of pre-mNK cells was recently associated with improved disease outcome in cancer patients. It is thus timely to revisit the functional attributes as well as the therapeutic potential of pre-mNK cells in line with their newly defined NK-cell precursor function.
format Online
Article
Text
id pubmed-3858890
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-38588902013-12-27 Revisiting the Prominent Anti-Tumoral Potential of Pre-mNK Cells Guimont-Desrochers, Fanny Lesage, Sylvie Front Immunol Immunology Interferon-producing killer dendritic cells (IKDC) were first described for their outstanding anti-tumoral properties. The “IKDC” terminology implied the description of a novel DC subset and initiated a debate on their cellular lineage origin. This debate shifted the focus away from their notable anti-tumoral potential. IKDC were recently redefined as precursors to mature NK (mNK) cells and consequently renamed pre-mNK cells. Importantly, a putative human equivalent of pre-mNK cells was recently associated with improved disease outcome in cancer patients. It is thus timely to revisit the functional attributes as well as the therapeutic potential of pre-mNK cells in line with their newly defined NK-cell precursor function. Frontiers Media S.A. 2013-12-11 /pmc/articles/PMC3858890/ /pubmed/24376447 http://dx.doi.org/10.3389/fimmu.2013.00446 Text en Copyright © 2013 Guimont-Desrochers and Lesage. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Guimont-Desrochers, Fanny
Lesage, Sylvie
Revisiting the Prominent Anti-Tumoral Potential of Pre-mNK Cells
title Revisiting the Prominent Anti-Tumoral Potential of Pre-mNK Cells
title_full Revisiting the Prominent Anti-Tumoral Potential of Pre-mNK Cells
title_fullStr Revisiting the Prominent Anti-Tumoral Potential of Pre-mNK Cells
title_full_unstemmed Revisiting the Prominent Anti-Tumoral Potential of Pre-mNK Cells
title_short Revisiting the Prominent Anti-Tumoral Potential of Pre-mNK Cells
title_sort revisiting the prominent anti-tumoral potential of pre-mnk cells
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858890/
https://www.ncbi.nlm.nih.gov/pubmed/24376447
http://dx.doi.org/10.3389/fimmu.2013.00446
work_keys_str_mv AT guimontdesrochersfanny revisitingtheprominentantitumoralpotentialofpremnkcells
AT lesagesylvie revisitingtheprominentantitumoralpotentialofpremnkcells