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Algorithms of Ancestral Gene Length Reconstruction

Ancestral sequence reconstruction is a well-known problem in molecular evolution. The problem presented in this study is inspired by sequence reconstruction, but instead of leaf-associated sequences we consider only their lengths. We call this problem ancestral gene length reconstruction. It is a pr...

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Detalles Bibliográficos
Autores principales: Bolshoy, Alexander, Kirzhner, Valery M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858891/
https://www.ncbi.nlm.nih.gov/pubmed/24371824
http://dx.doi.org/10.1155/2013/472163
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author Bolshoy, Alexander
Kirzhner, Valery M.
author_facet Bolshoy, Alexander
Kirzhner, Valery M.
author_sort Bolshoy, Alexander
collection PubMed
description Ancestral sequence reconstruction is a well-known problem in molecular evolution. The problem presented in this study is inspired by sequence reconstruction, but instead of leaf-associated sequences we consider only their lengths. We call this problem ancestral gene length reconstruction. It is a problem of finding an optimal labeling which minimizes the total length's sum of the edges, where both a tree and nonnegative integers associated with corresponding leaves of the tree are the input. In this paper we give a linear algorithm to solve the problem on binary trees for the Manhattan cost function s(v, w) = |π(v) − π(w)|.
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spelling pubmed-38588912013-12-26 Algorithms of Ancestral Gene Length Reconstruction Bolshoy, Alexander Kirzhner, Valery M. Biomed Res Int Research Article Ancestral sequence reconstruction is a well-known problem in molecular evolution. The problem presented in this study is inspired by sequence reconstruction, but instead of leaf-associated sequences we consider only their lengths. We call this problem ancestral gene length reconstruction. It is a problem of finding an optimal labeling which minimizes the total length's sum of the edges, where both a tree and nonnegative integers associated with corresponding leaves of the tree are the input. In this paper we give a linear algorithm to solve the problem on binary trees for the Manhattan cost function s(v, w) = |π(v) − π(w)|. Hindawi Publishing Corporation 2013 2013-11-26 /pmc/articles/PMC3858891/ /pubmed/24371824 http://dx.doi.org/10.1155/2013/472163 Text en Copyright © 2013 A. Bolshoy and V. M. Kirzhner. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bolshoy, Alexander
Kirzhner, Valery M.
Algorithms of Ancestral Gene Length Reconstruction
title Algorithms of Ancestral Gene Length Reconstruction
title_full Algorithms of Ancestral Gene Length Reconstruction
title_fullStr Algorithms of Ancestral Gene Length Reconstruction
title_full_unstemmed Algorithms of Ancestral Gene Length Reconstruction
title_short Algorithms of Ancestral Gene Length Reconstruction
title_sort algorithms of ancestral gene length reconstruction
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858891/
https://www.ncbi.nlm.nih.gov/pubmed/24371824
http://dx.doi.org/10.1155/2013/472163
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