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Algorithms of Ancestral Gene Length Reconstruction
Ancestral sequence reconstruction is a well-known problem in molecular evolution. The problem presented in this study is inspired by sequence reconstruction, but instead of leaf-associated sequences we consider only their lengths. We call this problem ancestral gene length reconstruction. It is a pr...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858891/ https://www.ncbi.nlm.nih.gov/pubmed/24371824 http://dx.doi.org/10.1155/2013/472163 |
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author | Bolshoy, Alexander Kirzhner, Valery M. |
author_facet | Bolshoy, Alexander Kirzhner, Valery M. |
author_sort | Bolshoy, Alexander |
collection | PubMed |
description | Ancestral sequence reconstruction is a well-known problem in molecular evolution. The problem presented in this study is inspired by sequence reconstruction, but instead of leaf-associated sequences we consider only their lengths. We call this problem ancestral gene length reconstruction. It is a problem of finding an optimal labeling which minimizes the total length's sum of the edges, where both a tree and nonnegative integers associated with corresponding leaves of the tree are the input. In this paper we give a linear algorithm to solve the problem on binary trees for the Manhattan cost function s(v, w) = |π(v) − π(w)|. |
format | Online Article Text |
id | pubmed-3858891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-38588912013-12-26 Algorithms of Ancestral Gene Length Reconstruction Bolshoy, Alexander Kirzhner, Valery M. Biomed Res Int Research Article Ancestral sequence reconstruction is a well-known problem in molecular evolution. The problem presented in this study is inspired by sequence reconstruction, but instead of leaf-associated sequences we consider only their lengths. We call this problem ancestral gene length reconstruction. It is a problem of finding an optimal labeling which minimizes the total length's sum of the edges, where both a tree and nonnegative integers associated with corresponding leaves of the tree are the input. In this paper we give a linear algorithm to solve the problem on binary trees for the Manhattan cost function s(v, w) = |π(v) − π(w)|. Hindawi Publishing Corporation 2013 2013-11-26 /pmc/articles/PMC3858891/ /pubmed/24371824 http://dx.doi.org/10.1155/2013/472163 Text en Copyright © 2013 A. Bolshoy and V. M. Kirzhner. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Bolshoy, Alexander Kirzhner, Valery M. Algorithms of Ancestral Gene Length Reconstruction |
title | Algorithms of Ancestral Gene Length Reconstruction |
title_full | Algorithms of Ancestral Gene Length Reconstruction |
title_fullStr | Algorithms of Ancestral Gene Length Reconstruction |
title_full_unstemmed | Algorithms of Ancestral Gene Length Reconstruction |
title_short | Algorithms of Ancestral Gene Length Reconstruction |
title_sort | algorithms of ancestral gene length reconstruction |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858891/ https://www.ncbi.nlm.nih.gov/pubmed/24371824 http://dx.doi.org/10.1155/2013/472163 |
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