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Improved Glucose-Stimulated Insulin Secretion by Selective Intraislet Inhibition of Angiotensin II Type 1 Receptor Expression in Isolated Islets of db/db Mice

Recent evidence supported the presence of a local renin-angiotensin system (RAS) in the pancreas, which is implicated in many physiological and pathophysiological processes. We utilized small interfering RNA (siRNA) to investigate the effects of angiotensin II type 1 receptor (AT1R) knockdown on glu...

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Detalles Bibliográficos
Autores principales:	Zhang, Zhen, Liu, Chunyan, Gan, Zhenhua, Wang, Xinyi, Yi, Qiuyan, Liu, Yanqing, Wang, Yingzhijie, Lu, Bin, Du, Hong, Shao, Jiaqing, Wang, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859026/ https://www.ncbi.nlm.nih.gov/pubmed/24371439 http://dx.doi.org/10.1155/2013/319586

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