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Attenuation of Myocardial Injury by HMGB1 Blockade during Ischemia/Reperfusion Is Toll-Like Receptor 2-Dependent

Genetic or pharmacological ablation of toll-like receptor 2 (TLR2) protects against myocardial ischemia/reperfusion injury (MI/R). However, the endogenous ligand responsible for TLR2 activation has not yet been detected. The objective of this study was to identify HMGB1 as an activator of TLR2 signa...

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Detalles Bibliográficos
Autores principales:	Mersmann, Jan, Iskandar, Franziska, Latsch, Kathrina, Habeck, Katharina, Sprunck, Vera, Zimmermann, René, Schumann, Ralf R., Zacharowski, Kai, Koch, Alexander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859028/ https://www.ncbi.nlm.nih.gov/pubmed/24371373 http://dx.doi.org/10.1155/2013/174168

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