Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation

Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modi...

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Detalles Bibliográficos
Autores principales: Shigdar, Sarah, Macdonald, Joanna, O'Connor, Michael, Wang, Tao, Xiang, Dongxi, Al.Shamaileh, Hadi, Qiao, Liang, Wei, Ming, Zhou, Shu-Feng, Zhu, Yimin, Kong, Lingxue, Bhattacharya, Santanu, Li, ChunGuang, Duan, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859083/
https://www.ncbi.nlm.nih.gov/pubmed/24152925
http://dx.doi.org/10.3390/s131013624
Descripción
Sumario:Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.

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