Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation

Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modi...

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Autores principales: Shigdar, Sarah, Macdonald, Joanna, O'Connor, Michael, Wang, Tao, Xiang, Dongxi, Al.Shamaileh, Hadi, Qiao, Liang, Wei, Ming, Zhou, Shu-Feng, Zhu, Yimin, Kong, Lingxue, Bhattacharya, Santanu, Li, ChunGuang, Duan, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859083/
https://www.ncbi.nlm.nih.gov/pubmed/24152925
http://dx.doi.org/10.3390/s131013624
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author Shigdar, Sarah
Macdonald, Joanna
O'Connor, Michael
Wang, Tao
Xiang, Dongxi
Al.Shamaileh, Hadi
Qiao, Liang
Wei, Ming
Zhou, Shu-Feng
Zhu, Yimin
Kong, Lingxue
Bhattacharya, Santanu
Li, ChunGuang
Duan, Wei
author_facet Shigdar, Sarah
Macdonald, Joanna
O'Connor, Michael
Wang, Tao
Xiang, Dongxi
Al.Shamaileh, Hadi
Qiao, Liang
Wei, Ming
Zhou, Shu-Feng
Zhu, Yimin
Kong, Lingxue
Bhattacharya, Santanu
Li, ChunGuang
Duan, Wei
author_sort Shigdar, Sarah
collection PubMed
description Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.
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spelling pubmed-38590832013-12-11 Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation Shigdar, Sarah Macdonald, Joanna O'Connor, Michael Wang, Tao Xiang, Dongxi Al.Shamaileh, Hadi Qiao, Liang Wei, Ming Zhou, Shu-Feng Zhu, Yimin Kong, Lingxue Bhattacharya, Santanu Li, ChunGuang Duan, Wei Sensors (Basel) Review Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents. Molecular Diversity Preservation International (MDPI) 2013-10-10 /pmc/articles/PMC3859083/ /pubmed/24152925 http://dx.doi.org/10.3390/s131013624 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Shigdar, Sarah
Macdonald, Joanna
O'Connor, Michael
Wang, Tao
Xiang, Dongxi
Al.Shamaileh, Hadi
Qiao, Liang
Wei, Ming
Zhou, Shu-Feng
Zhu, Yimin
Kong, Lingxue
Bhattacharya, Santanu
Li, ChunGuang
Duan, Wei
Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation
title Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation
title_full Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation
title_fullStr Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation
title_full_unstemmed Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation
title_short Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation
title_sort aptamers as theranostic agents: modifications, serum stability and functionalisation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859083/
https://www.ncbi.nlm.nih.gov/pubmed/24152925
http://dx.doi.org/10.3390/s131013624
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