Cargando…

Amauroderma rugosum (Blume & T. Nees) Torrend: Nutritional Composition and Antioxidant and Potential Anti-Inflammatory Properties

Amauroderma rugosum is a wild mushroom that is worn as a necklace by the indigenous communities in Malaysia to prevent fits and incessant crying by babies. The aim of this study was to investigate the nutritive composition and antioxidant potential and anti-inflammatory effects of A. rugosum extract...

Descripción completa

Detalles Bibliográficos
Autores principales: Chan, Pui-Mun, Kanagasabapathy, Gowri, Tan, Yee-Shin, Sabaratnam, Vikineswary, Kuppusamy, Umah Rani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859164/
https://www.ncbi.nlm.nih.gov/pubmed/24371454
http://dx.doi.org/10.1155/2013/304713
_version_ 1782295387855388672
author Chan, Pui-Mun
Kanagasabapathy, Gowri
Tan, Yee-Shin
Sabaratnam, Vikineswary
Kuppusamy, Umah Rani
author_facet Chan, Pui-Mun
Kanagasabapathy, Gowri
Tan, Yee-Shin
Sabaratnam, Vikineswary
Kuppusamy, Umah Rani
author_sort Chan, Pui-Mun
collection PubMed
description Amauroderma rugosum is a wild mushroom that is worn as a necklace by the indigenous communities in Malaysia to prevent fits and incessant crying by babies. The aim of this study was to investigate the nutritive composition and antioxidant potential and anti-inflammatory effects of A. rugosum extracts on LPS-stimulated RAW264.7 cells. Nutritional analysis of freeze-dried mycelia of A. rugosum (KUM 61131) from submerged culture indicated a predominant presence of carbohydrates, proteins, dietary fibre, phosphorus, potassium, and sodium. The ethanol crude extract (EE), its hexane (HF), ethyl acetate (EAF), and aqueous (AF) fractions of mycelia of A. rugosum grown in submerged culture were evaluated for antioxidant potential and anti-inflammatory effects. EAF exhibited the highest total phenolic content and the strongest antioxidant activity based on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays. HF showed dose-dependent inhibition of NO production in LPS-stimulated RAW264.7 cells and NO radical scavenging activity. Gas chromatographic analysis of HF revealed the presence of ethyl linoleate and ergosterol, compounds with known anti-inflammatory properties. In conclusion, the nutritive compositions and significant antioxidant potential and anti-inflammatory effects of mycelia extracts of A. rugosum have the potential to serve as a therapeutic agent or adjuvant in the management of inflammatory disorders.
format Online
Article
Text
id pubmed-3859164
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-38591642013-12-26 Amauroderma rugosum (Blume & T. Nees) Torrend: Nutritional Composition and Antioxidant and Potential Anti-Inflammatory Properties Chan, Pui-Mun Kanagasabapathy, Gowri Tan, Yee-Shin Sabaratnam, Vikineswary Kuppusamy, Umah Rani Evid Based Complement Alternat Med Research Article Amauroderma rugosum is a wild mushroom that is worn as a necklace by the indigenous communities in Malaysia to prevent fits and incessant crying by babies. The aim of this study was to investigate the nutritive composition and antioxidant potential and anti-inflammatory effects of A. rugosum extracts on LPS-stimulated RAW264.7 cells. Nutritional analysis of freeze-dried mycelia of A. rugosum (KUM 61131) from submerged culture indicated a predominant presence of carbohydrates, proteins, dietary fibre, phosphorus, potassium, and sodium. The ethanol crude extract (EE), its hexane (HF), ethyl acetate (EAF), and aqueous (AF) fractions of mycelia of A. rugosum grown in submerged culture were evaluated for antioxidant potential and anti-inflammatory effects. EAF exhibited the highest total phenolic content and the strongest antioxidant activity based on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays. HF showed dose-dependent inhibition of NO production in LPS-stimulated RAW264.7 cells and NO radical scavenging activity. Gas chromatographic analysis of HF revealed the presence of ethyl linoleate and ergosterol, compounds with known anti-inflammatory properties. In conclusion, the nutritive compositions and significant antioxidant potential and anti-inflammatory effects of mycelia extracts of A. rugosum have the potential to serve as a therapeutic agent or adjuvant in the management of inflammatory disorders. Hindawi Publishing Corporation 2013 2013-11-25 /pmc/articles/PMC3859164/ /pubmed/24371454 http://dx.doi.org/10.1155/2013/304713 Text en Copyright © 2013 Pui-Mun Chan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chan, Pui-Mun
Kanagasabapathy, Gowri
Tan, Yee-Shin
Sabaratnam, Vikineswary
Kuppusamy, Umah Rani
Amauroderma rugosum (Blume & T. Nees) Torrend: Nutritional Composition and Antioxidant and Potential Anti-Inflammatory Properties
title Amauroderma rugosum (Blume & T. Nees) Torrend: Nutritional Composition and Antioxidant and Potential Anti-Inflammatory Properties
title_full Amauroderma rugosum (Blume & T. Nees) Torrend: Nutritional Composition and Antioxidant and Potential Anti-Inflammatory Properties
title_fullStr Amauroderma rugosum (Blume & T. Nees) Torrend: Nutritional Composition and Antioxidant and Potential Anti-Inflammatory Properties
title_full_unstemmed Amauroderma rugosum (Blume & T. Nees) Torrend: Nutritional Composition and Antioxidant and Potential Anti-Inflammatory Properties
title_short Amauroderma rugosum (Blume & T. Nees) Torrend: Nutritional Composition and Antioxidant and Potential Anti-Inflammatory Properties
title_sort amauroderma rugosum (blume & t. nees) torrend: nutritional composition and antioxidant and potential anti-inflammatory properties
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859164/
https://www.ncbi.nlm.nih.gov/pubmed/24371454
http://dx.doi.org/10.1155/2013/304713
work_keys_str_mv AT chanpuimun amaurodermarugosumblumetneestorrendnutritionalcompositionandantioxidantandpotentialantiinflammatoryproperties
AT kanagasabapathygowri amaurodermarugosumblumetneestorrendnutritionalcompositionandantioxidantandpotentialantiinflammatoryproperties
AT tanyeeshin amaurodermarugosumblumetneestorrendnutritionalcompositionandantioxidantandpotentialantiinflammatoryproperties
AT sabaratnamvikineswary amaurodermarugosumblumetneestorrendnutritionalcompositionandantioxidantandpotentialantiinflammatoryproperties
AT kuppusamyumahrani amaurodermarugosumblumetneestorrendnutritionalcompositionandantioxidantandpotentialantiinflammatoryproperties