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A New Biomarkers Feature Pattern Consisting of TNF-α, IL-10, and IL-8 for Blood Stasis Syndrome with Myocardial Ischemia

Objective. To explore new diagnostic patterns for syndromes to overcome the insufficiency of obtainable macrocharacteristics and specific biomarkers. Methods. Chinese miniswines were subjected to Ameroid constrictor, placed around the proximal left anterior descending branch. On the 4th week, macroc...

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Autores principales: Guo, Shuzhen, Chen, Jianxin, Chuo, Wenjing, Liu, Lei, Feng, Xuanchao, Lian, Hongjian, Zheng, Lei, Wang, Yong, Xie, Hua, Luo, Liangtao, Zheng, Chenglong, Fu, Bangze, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859256/
https://www.ncbi.nlm.nih.gov/pubmed/24371451
http://dx.doi.org/10.1155/2013/130702
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author Guo, Shuzhen
Chen, Jianxin
Chuo, Wenjing
Liu, Lei
Feng, Xuanchao
Lian, Hongjian
Zheng, Lei
Wang, Yong
Xie, Hua
Luo, Liangtao
Zheng, Chenglong
Fu, Bangze
Wang, Wei
author_facet Guo, Shuzhen
Chen, Jianxin
Chuo, Wenjing
Liu, Lei
Feng, Xuanchao
Lian, Hongjian
Zheng, Lei
Wang, Yong
Xie, Hua
Luo, Liangtao
Zheng, Chenglong
Fu, Bangze
Wang, Wei
author_sort Guo, Shuzhen
collection PubMed
description Objective. To explore new diagnostic patterns for syndromes to overcome the insufficiency of obtainable macrocharacteristics and specific biomarkers. Methods. Chinese miniswines were subjected to Ameroid constrictor, placed around the proximal left anterior descending branch. On the 4th week, macrocharacteristics, coronary angiography, echocardiography, and hemorheology indices were detected for diagnosis. IL-1, IL-6, IL-8, IL-10, TNF-α, and hsCRP in serum were detected, and Decision Tree was built. Results. According to current official-issued standard, model animals matched the diagnosis of blood stasis syndrome with myocardial ischemia based on findings, including >90% occlusion, attenuated left ventricular segmental motion, dark red or purple tongues, and higher blood viscosity. Significant decrease of IL-10 and increase of TNF-α were found in model animals. However, in the Decision Tree, besides IL-10 and TNF-α, IL-8 helped to increase the accuracy of classification to 86%. Conclusions. The Decision Tree building with TNF-α, IL-10, and IL-8 is helpful for the diagnosis of blood stasis syndrome in myocardial ischemia animals. What is more is that our data set up a new path to the differentiation of syndrome by feature patterns consisting of multiple biomarkers not only for animals but also for patients. We believe that it will contribute to the standardization and international application of syndromes.
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spelling pubmed-38592562013-12-26 A New Biomarkers Feature Pattern Consisting of TNF-α, IL-10, and IL-8 for Blood Stasis Syndrome with Myocardial Ischemia Guo, Shuzhen Chen, Jianxin Chuo, Wenjing Liu, Lei Feng, Xuanchao Lian, Hongjian Zheng, Lei Wang, Yong Xie, Hua Luo, Liangtao Zheng, Chenglong Fu, Bangze Wang, Wei Evid Based Complement Alternat Med Research Article Objective. To explore new diagnostic patterns for syndromes to overcome the insufficiency of obtainable macrocharacteristics and specific biomarkers. Methods. Chinese miniswines were subjected to Ameroid constrictor, placed around the proximal left anterior descending branch. On the 4th week, macrocharacteristics, coronary angiography, echocardiography, and hemorheology indices were detected for diagnosis. IL-1, IL-6, IL-8, IL-10, TNF-α, and hsCRP in serum were detected, and Decision Tree was built. Results. According to current official-issued standard, model animals matched the diagnosis of blood stasis syndrome with myocardial ischemia based on findings, including >90% occlusion, attenuated left ventricular segmental motion, dark red or purple tongues, and higher blood viscosity. Significant decrease of IL-10 and increase of TNF-α were found in model animals. However, in the Decision Tree, besides IL-10 and TNF-α, IL-8 helped to increase the accuracy of classification to 86%. Conclusions. The Decision Tree building with TNF-α, IL-10, and IL-8 is helpful for the diagnosis of blood stasis syndrome in myocardial ischemia animals. What is more is that our data set up a new path to the differentiation of syndrome by feature patterns consisting of multiple biomarkers not only for animals but also for patients. We believe that it will contribute to the standardization and international application of syndromes. Hindawi Publishing Corporation 2013 2013-11-25 /pmc/articles/PMC3859256/ /pubmed/24371451 http://dx.doi.org/10.1155/2013/130702 Text en Copyright © 2013 Shuzhen Guo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Guo, Shuzhen
Chen, Jianxin
Chuo, Wenjing
Liu, Lei
Feng, Xuanchao
Lian, Hongjian
Zheng, Lei
Wang, Yong
Xie, Hua
Luo, Liangtao
Zheng, Chenglong
Fu, Bangze
Wang, Wei
A New Biomarkers Feature Pattern Consisting of TNF-α, IL-10, and IL-8 for Blood Stasis Syndrome with Myocardial Ischemia
title A New Biomarkers Feature Pattern Consisting of TNF-α, IL-10, and IL-8 for Blood Stasis Syndrome with Myocardial Ischemia
title_full A New Biomarkers Feature Pattern Consisting of TNF-α, IL-10, and IL-8 for Blood Stasis Syndrome with Myocardial Ischemia
title_fullStr A New Biomarkers Feature Pattern Consisting of TNF-α, IL-10, and IL-8 for Blood Stasis Syndrome with Myocardial Ischemia
title_full_unstemmed A New Biomarkers Feature Pattern Consisting of TNF-α, IL-10, and IL-8 for Blood Stasis Syndrome with Myocardial Ischemia
title_short A New Biomarkers Feature Pattern Consisting of TNF-α, IL-10, and IL-8 for Blood Stasis Syndrome with Myocardial Ischemia
title_sort new biomarkers feature pattern consisting of tnf-α, il-10, and il-8 for blood stasis syndrome with myocardial ischemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859256/
https://www.ncbi.nlm.nih.gov/pubmed/24371451
http://dx.doi.org/10.1155/2013/130702
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