Genetic and Non-Genetic Determinants of Raltegravir Penetration into Cerebrospinal Fluid: A Single Arm Pharmacokinetic Study

BACKGROUND: Antiretroviral drugs vary in their central nervous system penetration, with better penetration possibly conferring neurocognitive benefit during human immunodeficiency virus (HIV) therapy. The efflux transporter gene ABCB1 is expressed in the blood-brain barrier, and an ABCB1 variant (34...

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Detalles Bibliográficos
Autores principales: Johnson, Daniel H., Sutherland, Deborah, Acosta, Edward P., Erdem, Husamettin, Richardson, Danielle, Haas, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859605/
https://www.ncbi.nlm.nih.gov/pubmed/24349334
http://dx.doi.org/10.1371/journal.pone.0082672

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