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Is Obesity a Risk Factor for Vaccine Non-Responsiveness?
Understanding the link between vaccine immunogenicity and efficacy is currently a major focus in HIV research. Consequently, recent developments in the HIV-1 vaccine field have led to a closer look at immune responses to known efficacious vaccines. We undertook a study to explore clinical predictors...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859613/ https://www.ncbi.nlm.nih.gov/pubmed/24349359 http://dx.doi.org/10.1371/journal.pone.0082779 |
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author | Young, Katherine M. Gray, Clive M. Bekker, Linda-Gail |
author_facet | Young, Katherine M. Gray, Clive M. Bekker, Linda-Gail |
author_sort | Young, Katherine M. |
collection | PubMed |
description | Understanding the link between vaccine immunogenicity and efficacy is currently a major focus in HIV research. Consequently, recent developments in the HIV-1 vaccine field have led to a closer look at immune responses to known efficacious vaccines. We undertook a study to explore clinical predictors of vaccine efficacy following recombinant hepatitis B (rHBV) vaccination in a cohort of HIV-uninfected, hepatitis B virus naïve women living in a peri-urban setting in Cape Town. Our aim was to define host biological risk factors associated with lack of vaccine uptake. We found a significant association (p=0.009) between body mass index (BMI) and lack of vaccine-specific IgG titre (<10mIU/mL). Obese individuals (BMI ≥ 30kg/m(2)) were significantly more likely to be non-responders following 2 rHBV vaccine doses (Adjusted Odds Ratio of 8.75; p=0.043). There was no observed association between vaccine responses and age, method of contraception or time from vaccination to antibody measurement. These data suggest that obesity-associated factors interfere with vaccine immunogenicity and possible efficacy. |
format | Online Article Text |
id | pubmed-3859613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38596132013-12-13 Is Obesity a Risk Factor for Vaccine Non-Responsiveness? Young, Katherine M. Gray, Clive M. Bekker, Linda-Gail PLoS One Research Article Understanding the link between vaccine immunogenicity and efficacy is currently a major focus in HIV research. Consequently, recent developments in the HIV-1 vaccine field have led to a closer look at immune responses to known efficacious vaccines. We undertook a study to explore clinical predictors of vaccine efficacy following recombinant hepatitis B (rHBV) vaccination in a cohort of HIV-uninfected, hepatitis B virus naïve women living in a peri-urban setting in Cape Town. Our aim was to define host biological risk factors associated with lack of vaccine uptake. We found a significant association (p=0.009) between body mass index (BMI) and lack of vaccine-specific IgG titre (<10mIU/mL). Obese individuals (BMI ≥ 30kg/m(2)) were significantly more likely to be non-responders following 2 rHBV vaccine doses (Adjusted Odds Ratio of 8.75; p=0.043). There was no observed association between vaccine responses and age, method of contraception or time from vaccination to antibody measurement. These data suggest that obesity-associated factors interfere with vaccine immunogenicity and possible efficacy. Public Library of Science 2013-12-11 /pmc/articles/PMC3859613/ /pubmed/24349359 http://dx.doi.org/10.1371/journal.pone.0082779 Text en © 2013 Young et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Young, Katherine M. Gray, Clive M. Bekker, Linda-Gail Is Obesity a Risk Factor for Vaccine Non-Responsiveness? |
title | Is Obesity a Risk Factor for Vaccine Non-Responsiveness? |
title_full | Is Obesity a Risk Factor for Vaccine Non-Responsiveness? |
title_fullStr | Is Obesity a Risk Factor for Vaccine Non-Responsiveness? |
title_full_unstemmed | Is Obesity a Risk Factor for Vaccine Non-Responsiveness? |
title_short | Is Obesity a Risk Factor for Vaccine Non-Responsiveness? |
title_sort | is obesity a risk factor for vaccine non-responsiveness? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859613/ https://www.ncbi.nlm.nih.gov/pubmed/24349359 http://dx.doi.org/10.1371/journal.pone.0082779 |
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