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Functional Complementation of sir2Δ Yeast Mutation by the Human Orthologous Gene SIRT1
Sirtuins, class III histone deacetylases, are proteins homologous to the yeast protein Sir2p. Mammalian Sirt1 has been shown to be involved in energy metabolism, brain functions, inflammation and aging through its deacetylase activity, acting on both histone and non-histone substrates. In order to v...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859646/ https://www.ncbi.nlm.nih.gov/pubmed/24349441 http://dx.doi.org/10.1371/journal.pone.0083114 |