Lin28 Induces Epithelial-to-Mesenchymal Transition and Stemness via Downregulation of Let-7a in Breast Cancer Cells

The RNA-binding protein Lin28 is known to promote malignancy by inhibiting the biogenesis of let-7, which functions as a tumor suppressor. However, the role of the Lin28/let-7 axis in the epithelial-to-mesenchymal transition (EMT) and stemness in breast cancer has not been clearly expatiated. In our...

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Detalles Bibliográficos
Autores principales: Liu, Yujie, Li, Haiyan, Feng, Juan, Cui, Xiuying, Huang, Wei, Li, Yudong, Su, Fengxi, Liu, Qiang, Zhu, Jiujun, Lv, Xiaobin, Chen, Jianing, Huang, Di, Yu, Fengyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859647/
https://www.ncbi.nlm.nih.gov/pubmed/24349438
http://dx.doi.org/10.1371/journal.pone.0083083

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