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Effect of Caffeine-Containing Beverage Consumption on Serum Alanine Aminotransferase Levels in Patients with Chronic Hepatitis C Virus Infection: A Hospital-Based Cohort Study

INTRODUCTION: To date, there have been no prospective studies examining the effect of coffee consumption on serum alanine aminotransferase (ALT) level among individuals infected with the hepatitis C virus (HCV). We conducted a hospital-based cohort study among patients with chronic HCV infection to...

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Autores principales: Sasaki, Yachiyo, Ohfuji, Satoko, Fukushima, Wakaba, Tamori, Akihiro, Enomoto, Masaru, Habu, Daiki, Iwai, Shuji, Uchida-Kobayashi, Sawako, Fujii, Hideki, Shiomi, Susumu, Kawada, Norifumi, Hirota, Yoshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859663/
https://www.ncbi.nlm.nih.gov/pubmed/24349501
http://dx.doi.org/10.1371/journal.pone.0083382
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author Sasaki, Yachiyo
Ohfuji, Satoko
Fukushima, Wakaba
Tamori, Akihiro
Enomoto, Masaru
Habu, Daiki
Iwai, Shuji
Uchida-Kobayashi, Sawako
Fujii, Hideki
Shiomi, Susumu
Kawada, Norifumi
Hirota, Yoshio
author_facet Sasaki, Yachiyo
Ohfuji, Satoko
Fukushima, Wakaba
Tamori, Akihiro
Enomoto, Masaru
Habu, Daiki
Iwai, Shuji
Uchida-Kobayashi, Sawako
Fujii, Hideki
Shiomi, Susumu
Kawada, Norifumi
Hirota, Yoshio
author_sort Sasaki, Yachiyo
collection PubMed
description INTRODUCTION: To date, there have been no prospective studies examining the effect of coffee consumption on serum alanine aminotransferase (ALT) level among individuals infected with the hepatitis C virus (HCV). We conducted a hospital-based cohort study among patients with chronic HCV infection to assess an association between baseline coffee consumption and subsequent ALT levels for 12 months. MATERIALS AND METHODS: From 1 August 2005 to 31 July 2006, total 376 HCV-RNA positive patients were recruited. A baseline questionnaire elicited information on the frequency of coffee consumption and other caffeine-containing beverages. ALT level as a study outcome was followed through the patients’ medical records during 12 months. The association between baseline beverage consumption and subsequent ALT levels was evaluated separately among patients with baseline ALT levels within normal range (≤45 IU/L) and among those with higher ALT levels (>45 IU/L). RESULTS: Among 229 patients with baseline ALT levels within normal range, 186 (81%) retained normal ALT levels at 12 months after recruitment. Daily drinkers of filtered coffee were three times more likely to preserve a normal ALT level than non-drinkers (OR=2.74; P=0.037). However, decaffeinated coffee drinkers had a somewhat inverse effect for sustained normal ALT levels, with marginal significance (OR=0.26; P=0.076). In addition, among 147 patients with higher baseline ALT levels, 39 patients (27%) had ALT reductions of ≥20 IU/L at 12 months after recruitment. Daily drinkers of filtered coffee had a significantly increased OR for ALT reduction (OR=3.79; P=0.034). However, in decaffeinated coffee drinkers, OR could not be calculated because no patients had ALT reduction. CONCLUSION: Among patients with chronic HCV infection, daily consumption of filtered coffee may have a beneficial effect on the stabilization of ALT levels.
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spelling pubmed-38596632013-12-13 Effect of Caffeine-Containing Beverage Consumption on Serum Alanine Aminotransferase Levels in Patients with Chronic Hepatitis C Virus Infection: A Hospital-Based Cohort Study Sasaki, Yachiyo Ohfuji, Satoko Fukushima, Wakaba Tamori, Akihiro Enomoto, Masaru Habu, Daiki Iwai, Shuji Uchida-Kobayashi, Sawako Fujii, Hideki Shiomi, Susumu Kawada, Norifumi Hirota, Yoshio PLoS One Research Article INTRODUCTION: To date, there have been no prospective studies examining the effect of coffee consumption on serum alanine aminotransferase (ALT) level among individuals infected with the hepatitis C virus (HCV). We conducted a hospital-based cohort study among patients with chronic HCV infection to assess an association between baseline coffee consumption and subsequent ALT levels for 12 months. MATERIALS AND METHODS: From 1 August 2005 to 31 July 2006, total 376 HCV-RNA positive patients were recruited. A baseline questionnaire elicited information on the frequency of coffee consumption and other caffeine-containing beverages. ALT level as a study outcome was followed through the patients’ medical records during 12 months. The association between baseline beverage consumption and subsequent ALT levels was evaluated separately among patients with baseline ALT levels within normal range (≤45 IU/L) and among those with higher ALT levels (>45 IU/L). RESULTS: Among 229 patients with baseline ALT levels within normal range, 186 (81%) retained normal ALT levels at 12 months after recruitment. Daily drinkers of filtered coffee were three times more likely to preserve a normal ALT level than non-drinkers (OR=2.74; P=0.037). However, decaffeinated coffee drinkers had a somewhat inverse effect for sustained normal ALT levels, with marginal significance (OR=0.26; P=0.076). In addition, among 147 patients with higher baseline ALT levels, 39 patients (27%) had ALT reductions of ≥20 IU/L at 12 months after recruitment. Daily drinkers of filtered coffee had a significantly increased OR for ALT reduction (OR=3.79; P=0.034). However, in decaffeinated coffee drinkers, OR could not be calculated because no patients had ALT reduction. CONCLUSION: Among patients with chronic HCV infection, daily consumption of filtered coffee may have a beneficial effect on the stabilization of ALT levels. Public Library of Science 2013-12-11 /pmc/articles/PMC3859663/ /pubmed/24349501 http://dx.doi.org/10.1371/journal.pone.0083382 Text en © 2013 Sasaki et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Sasaki, Yachiyo
Ohfuji, Satoko
Fukushima, Wakaba
Tamori, Akihiro
Enomoto, Masaru
Habu, Daiki
Iwai, Shuji
Uchida-Kobayashi, Sawako
Fujii, Hideki
Shiomi, Susumu
Kawada, Norifumi
Hirota, Yoshio
Effect of Caffeine-Containing Beverage Consumption on Serum Alanine Aminotransferase Levels in Patients with Chronic Hepatitis C Virus Infection: A Hospital-Based Cohort Study
title Effect of Caffeine-Containing Beverage Consumption on Serum Alanine Aminotransferase Levels in Patients with Chronic Hepatitis C Virus Infection: A Hospital-Based Cohort Study
title_full Effect of Caffeine-Containing Beverage Consumption on Serum Alanine Aminotransferase Levels in Patients with Chronic Hepatitis C Virus Infection: A Hospital-Based Cohort Study
title_fullStr Effect of Caffeine-Containing Beverage Consumption on Serum Alanine Aminotransferase Levels in Patients with Chronic Hepatitis C Virus Infection: A Hospital-Based Cohort Study
title_full_unstemmed Effect of Caffeine-Containing Beverage Consumption on Serum Alanine Aminotransferase Levels in Patients with Chronic Hepatitis C Virus Infection: A Hospital-Based Cohort Study
title_short Effect of Caffeine-Containing Beverage Consumption on Serum Alanine Aminotransferase Levels in Patients with Chronic Hepatitis C Virus Infection: A Hospital-Based Cohort Study
title_sort effect of caffeine-containing beverage consumption on serum alanine aminotransferase levels in patients with chronic hepatitis c virus infection: a hospital-based cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859663/
https://www.ncbi.nlm.nih.gov/pubmed/24349501
http://dx.doi.org/10.1371/journal.pone.0083382
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