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The contribution of nutrient metal acquisition and metabolism to Acinetobacter baumannii survival within the host
Acinetobacter baumannii is a significant contributor to intensive care unit (ICU) mortality causing numerous types of infection in this susceptible ICU population, most notably ventilator-associated pneumonia. The substantial disease burden attributed to A. baumannii and the rapid acquisition of ant...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859900/ https://www.ncbi.nlm.nih.gov/pubmed/24377089 http://dx.doi.org/10.3389/fcimb.2013.00095 |
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author | Mortensen, Brittany L. Skaar, Eric P. |
author_facet | Mortensen, Brittany L. Skaar, Eric P. |
author_sort | Mortensen, Brittany L. |
collection | PubMed |
description | Acinetobacter baumannii is a significant contributor to intensive care unit (ICU) mortality causing numerous types of infection in this susceptible ICU population, most notably ventilator-associated pneumonia. The substantial disease burden attributed to A. baumannii and the rapid acquisition of antibiotic resistance make this bacterium a serious health care threat. A. baumannii is equipped to tolerate the hostile host environment through modification of its metabolism and nutritional needs. Among these adaptations is the evolution of mechanisms to acquire nutrient metals that are sequestered by the host as a defense against infection. Although all bacteria require nutrient metals, there is diversity in the particular metal needs among species and within varying tissue types and bacterial lifecycles. A. baumannii is well-equipped with the metal homeostatic systems required for the colonization of a diverse array of tissues. Specifically, iron and zinc homeostasis is important for A. baumannii interactions with biotic surfaces and for growth within vertebrates. This review discusses what is currently known regarding the interaction of A. baumannii with vertebrate cells with a particular emphasis on the contributions of metal homeostasis systems. Overall, published research supports the utility of exploiting these systems as targets for the development of much-needed antimicrobials against this emerging infectious threat. |
format | Online Article Text |
id | pubmed-3859900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-38599002013-12-27 The contribution of nutrient metal acquisition and metabolism to Acinetobacter baumannii survival within the host Mortensen, Brittany L. Skaar, Eric P. Front Cell Infect Microbiol Microbiology Acinetobacter baumannii is a significant contributor to intensive care unit (ICU) mortality causing numerous types of infection in this susceptible ICU population, most notably ventilator-associated pneumonia. The substantial disease burden attributed to A. baumannii and the rapid acquisition of antibiotic resistance make this bacterium a serious health care threat. A. baumannii is equipped to tolerate the hostile host environment through modification of its metabolism and nutritional needs. Among these adaptations is the evolution of mechanisms to acquire nutrient metals that are sequestered by the host as a defense against infection. Although all bacteria require nutrient metals, there is diversity in the particular metal needs among species and within varying tissue types and bacterial lifecycles. A. baumannii is well-equipped with the metal homeostatic systems required for the colonization of a diverse array of tissues. Specifically, iron and zinc homeostasis is important for A. baumannii interactions with biotic surfaces and for growth within vertebrates. This review discusses what is currently known regarding the interaction of A. baumannii with vertebrate cells with a particular emphasis on the contributions of metal homeostasis systems. Overall, published research supports the utility of exploiting these systems as targets for the development of much-needed antimicrobials against this emerging infectious threat. Frontiers Media S.A. 2013-12-12 /pmc/articles/PMC3859900/ /pubmed/24377089 http://dx.doi.org/10.3389/fcimb.2013.00095 Text en Copyright © 2013 Mortensen and Skaar. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Mortensen, Brittany L. Skaar, Eric P. The contribution of nutrient metal acquisition and metabolism to Acinetobacter baumannii survival within the host |
title | The contribution of nutrient metal acquisition and metabolism to Acinetobacter baumannii survival within the host |
title_full | The contribution of nutrient metal acquisition and metabolism to Acinetobacter baumannii survival within the host |
title_fullStr | The contribution of nutrient metal acquisition and metabolism to Acinetobacter baumannii survival within the host |
title_full_unstemmed | The contribution of nutrient metal acquisition and metabolism to Acinetobacter baumannii survival within the host |
title_short | The contribution of nutrient metal acquisition and metabolism to Acinetobacter baumannii survival within the host |
title_sort | contribution of nutrient metal acquisition and metabolism to acinetobacter baumannii survival within the host |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859900/ https://www.ncbi.nlm.nih.gov/pubmed/24377089 http://dx.doi.org/10.3389/fcimb.2013.00095 |
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