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Epigenetic status of LINE-1 predicts clinical outcome in early-stage rectal cancer

BACKGROUND: We evaluated the clinical prognostic value of methylation of two non-coding repeat sequences, long interspersed element 1 (LINE-1) and Alu, in rectal tumour tissues. In addition to DNA methylation, expression of histone modifications H3K27me3 and H3K9Ac was studied in this patient cohort...

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Detalles Bibliográficos
Autores principales:	Benard, A, van de Velde, C J H, Lessard, L, Putter, H, Takeshima, L, Kuppen, P J K, Hoon, D S B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859941/ https://www.ncbi.nlm.nih.gov/pubmed/24220694 http://dx.doi.org/10.1038/bjc.2013.654

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