Role of endoplasmic reticulum stress induction by the plant toxin, persin, in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells

BACKGROUND: Persin is a plant toxin that displays synergistic cytotoxicity with tamoxifen in human breast cancer cell lines. Here, we examined the ability of persin to circumvent tamoxifen resistance and delineated the intracellular signalling pathways involved. METHODS: The induction of apoptosis i...

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Detalles Bibliográficos
Autores principales: McCloy, R A, Shelley, E J, Roberts, C G, Boslem, E, Biden, T J, Nicholson, R I, Gee, J M, Sutherland, R L, Musgrove, E A, Burgess, A, Butt, A J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859954/
https://www.ncbi.nlm.nih.gov/pubmed/24178758
http://dx.doi.org/10.1038/bjc.2013.693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859954/
https://www.ncbi.nlm.nih.gov/pubmed/24178758
http://dx.doi.org/10.1038/bjc.2013.693

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