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Alcoholic Lung Disease

In addition to its well-known association with lung infection (i.e., pneumonia), alcohol abuse now is recognized as an independent factor that increases by three- to four-fold the incidence of the acute respiratory distress syndrome, a severe form of acute lung injury with a mortality rate of 40 to...

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Detalles Bibliográficos
Autores principales: Kershaw, Corey D., Guidot, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute on Alcohol Abuse and Alcoholism 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860447/
https://www.ncbi.nlm.nih.gov/pubmed/23584753
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author Kershaw, Corey D.
Guidot, David M.
author_facet Kershaw, Corey D.
Guidot, David M.
author_sort Kershaw, Corey D.
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description In addition to its well-known association with lung infection (i.e., pneumonia), alcohol abuse now is recognized as an independent factor that increases by three- to four-fold the incidence of the acute respiratory distress syndrome, a severe form of acute lung injury with a mortality rate of 40 to 50 percent. This translates to tens of thousands of excess deaths in the United States each year from alcohol-mediated lung injury, which is comparable to scarring of the liver (i.e., cirrhosis) in terms of alcohol-related mortality. Experimental and clinical studies are shedding light on the basic mechanisms by which alcohol abuse predisposes some people to both acute lung injury and pneumonia. At the same time, novel therapeutic targets could be utilized in treating these uniquely vulnerable people. However, there have been no systems biological approaches to the study of the alcoholic lung to date. This is in part because the association between alcohol abuse and acute lung injury was made relatively recently and remains largely unrecognized, even by lung researchers. In parallel, efforts to study complex diseases such as acute lung injury and pneumonia using a genomics and/or proteomics approach, which involves the study of an organism’s genes and/or proteins, still are in their infancy. However, the alcoholic lung represents a clear example of environment–host interactions that should be well suited for such applications.
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spelling pubmed-38604472014-01-13 Alcoholic Lung Disease Kershaw, Corey D. Guidot, David M. Alcohol Res Health Putting Systems Biology Approaches into Practice In addition to its well-known association with lung infection (i.e., pneumonia), alcohol abuse now is recognized as an independent factor that increases by three- to four-fold the incidence of the acute respiratory distress syndrome, a severe form of acute lung injury with a mortality rate of 40 to 50 percent. This translates to tens of thousands of excess deaths in the United States each year from alcohol-mediated lung injury, which is comparable to scarring of the liver (i.e., cirrhosis) in terms of alcohol-related mortality. Experimental and clinical studies are shedding light on the basic mechanisms by which alcohol abuse predisposes some people to both acute lung injury and pneumonia. At the same time, novel therapeutic targets could be utilized in treating these uniquely vulnerable people. However, there have been no systems biological approaches to the study of the alcoholic lung to date. This is in part because the association between alcohol abuse and acute lung injury was made relatively recently and remains largely unrecognized, even by lung researchers. In parallel, efforts to study complex diseases such as acute lung injury and pneumonia using a genomics and/or proteomics approach, which involves the study of an organism’s genes and/or proteins, still are in their infancy. However, the alcoholic lung represents a clear example of environment–host interactions that should be well suited for such applications. National Institute on Alcohol Abuse and Alcoholism 2008 /pmc/articles/PMC3860447/ /pubmed/23584753 Text en http://creativecommons.org/publicdomain/mark/1.0/ Unless otherwise noted in the text, all material appearing in this journal is in the public domain and may be reproduced without permission. Citation of the source is appreciated.
spellingShingle Putting Systems Biology Approaches into Practice
Kershaw, Corey D.
Guidot, David M.
Alcoholic Lung Disease
title Alcoholic Lung Disease
title_full Alcoholic Lung Disease
title_fullStr Alcoholic Lung Disease
title_full_unstemmed Alcoholic Lung Disease
title_short Alcoholic Lung Disease
title_sort alcoholic lung disease
topic Putting Systems Biology Approaches into Practice
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860447/
https://www.ncbi.nlm.nih.gov/pubmed/23584753
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