Cargando…

Metabolomics in Alcohol Research and Drug Development

Developers of new medications need to describe and predict the functional attributes of test compounds administered to cells, animals, and humans. Today, researchers increasingly appreciate the role that intermediary products (i.e., metabolites) generated in the course of various metabolic pathways...

Descripción completa

Detalles Bibliográficos
Autores principales: Harrigan, George G., Maguire, Greg, Boros, Laszlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute on Alcohol Abuse and Alcoholism 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860450/
_version_ 1782295541717139456
author Harrigan, George G.
Maguire, Greg
Boros, Laszlo
author_facet Harrigan, George G.
Maguire, Greg
Boros, Laszlo
author_sort Harrigan, George G.
collection PubMed
description Developers of new medications need to describe and predict the functional attributes of test compounds administered to cells, animals, and humans. Today, researchers increasingly appreciate the role that intermediary products (i.e., metabolites) generated in the course of various metabolic pathways play in both health and disease states and how their analysis can support development of new medications. Advances in analytical and computational techniques have facilitated the rise of new and powerful tools for measuring metabolic and biochemical pathways in such complex systems. Metabolomics—a systems biology approach to characterizing metabolites produced in biochemical pathways—is contributing to many studies of disease progression and treatment, although it has not yet been extensively applied in research on metabolic perturbations associated with alcohol abuse. However, numerous metabolomic approaches may contribute to alcohol-related research, as illustrated by studies on alcohol-related metabolic dysfunctions such as (1) alterations in fat metabolism and (2) thiamine deficiency. By further increasing the number and types of metabolites that can be measured in a given biological sample, metabolomic approaches may be able to help define the role of the many different metabolic pathways affected by alcohol abuse and support discovery and development of novel medications for the treatment of alcoholism and related conditions.
format Online
Article
Text
id pubmed-3860450
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher National Institute on Alcohol Abuse and Alcoholism
record_format MEDLINE/PubMed
spelling pubmed-38604502014-01-13 Metabolomics in Alcohol Research and Drug Development Harrigan, George G. Maguire, Greg Boros, Laszlo Alcohol Res Health Articles Developers of new medications need to describe and predict the functional attributes of test compounds administered to cells, animals, and humans. Today, researchers increasingly appreciate the role that intermediary products (i.e., metabolites) generated in the course of various metabolic pathways play in both health and disease states and how their analysis can support development of new medications. Advances in analytical and computational techniques have facilitated the rise of new and powerful tools for measuring metabolic and biochemical pathways in such complex systems. Metabolomics—a systems biology approach to characterizing metabolites produced in biochemical pathways—is contributing to many studies of disease progression and treatment, although it has not yet been extensively applied in research on metabolic perturbations associated with alcohol abuse. However, numerous metabolomic approaches may contribute to alcohol-related research, as illustrated by studies on alcohol-related metabolic dysfunctions such as (1) alterations in fat metabolism and (2) thiamine deficiency. By further increasing the number and types of metabolites that can be measured in a given biological sample, metabolomic approaches may be able to help define the role of the many different metabolic pathways affected by alcohol abuse and support discovery and development of novel medications for the treatment of alcoholism and related conditions. National Institute on Alcohol Abuse and Alcoholism 2008 /pmc/articles/PMC3860450/ Text en http://creativecommons.org/publicdomain/mark/1.0/ Unless otherwise noted in the text, all material appearing in this journal is in the public domain and may be reproduced without permission. Citation of the source is appreciated.
spellingShingle Articles
Harrigan, George G.
Maguire, Greg
Boros, Laszlo
Metabolomics in Alcohol Research and Drug Development
title Metabolomics in Alcohol Research and Drug Development
title_full Metabolomics in Alcohol Research and Drug Development
title_fullStr Metabolomics in Alcohol Research and Drug Development
title_full_unstemmed Metabolomics in Alcohol Research and Drug Development
title_short Metabolomics in Alcohol Research and Drug Development
title_sort metabolomics in alcohol research and drug development
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860450/
work_keys_str_mv AT harrigangeorgeg metabolomicsinalcoholresearchanddrugdevelopment
AT maguiregreg metabolomicsinalcoholresearchanddrugdevelopment
AT boroslaszlo metabolomicsinalcoholresearchanddrugdevelopment