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Focus On: Alcohol and the Liver

Thirty-five years ago Charles Lieber and colleagues (1975) published a seminal article in liver research, showing that alcohol itself is the primary cause for the higher prevalence of liver disease seen in alcoholic patients and not dietary deficiencies and malnutrition that often accompany alcoholi...

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Detalles Bibliográficos
Autores principales: Szabo, Gyongyi, Mandrekar, Pranoti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute on Alcohol Abuse and Alcoholism 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860520/
https://www.ncbi.nlm.nih.gov/pubmed/23579939
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author Szabo, Gyongyi
Mandrekar, Pranoti
author_facet Szabo, Gyongyi
Mandrekar, Pranoti
author_sort Szabo, Gyongyi
collection PubMed
description Thirty-five years ago Charles Lieber and colleagues (1975) published a seminal article in liver research, showing that alcohol itself is the primary cause for the higher prevalence of liver disease seen in alcoholic patients and not dietary deficiencies and malnutrition that often accompany alcoholism. Their groundbreaking research dispelled previously held theories that alcohol was not a major cause of liver damage and led to several decades of study of the deleterious effects of alcohol and its metabolism on the liver. Since that early study, clinical and experimental studies have continued to show a firm connection between high amounts of alcohol consumption and liver disease. This article tracks advances in alcohol-related liver disease research over the past 40 years and describes how these discoveries are helping scientists to gain insight into therapeutic targets that may help to combat this life-threatening disease.
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spelling pubmed-38605202014-01-06 Focus On: Alcohol and the Liver Szabo, Gyongyi Mandrekar, Pranoti Alcohol Res Health Alcohol and Health Thirty-five years ago Charles Lieber and colleagues (1975) published a seminal article in liver research, showing that alcohol itself is the primary cause for the higher prevalence of liver disease seen in alcoholic patients and not dietary deficiencies and malnutrition that often accompany alcoholism. Their groundbreaking research dispelled previously held theories that alcohol was not a major cause of liver damage and led to several decades of study of the deleterious effects of alcohol and its metabolism on the liver. Since that early study, clinical and experimental studies have continued to show a firm connection between high amounts of alcohol consumption and liver disease. This article tracks advances in alcohol-related liver disease research over the past 40 years and describes how these discoveries are helping scientists to gain insight into therapeutic targets that may help to combat this life-threatening disease. National Institute on Alcohol Abuse and Alcoholism 2010 /pmc/articles/PMC3860520/ /pubmed/23579939 Text en
spellingShingle Alcohol and Health
Szabo, Gyongyi
Mandrekar, Pranoti
Focus On: Alcohol and the Liver
title Focus On: Alcohol and the Liver
title_full Focus On: Alcohol and the Liver
title_fullStr Focus On: Alcohol and the Liver
title_full_unstemmed Focus On: Alcohol and the Liver
title_short Focus On: Alcohol and the Liver
title_sort focus on: alcohol and the liver
topic Alcohol and Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860520/
https://www.ncbi.nlm.nih.gov/pubmed/23579939
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