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Focus On: Alcohol and the Liver
Thirty-five years ago Charles Lieber and colleagues (1975) published a seminal article in liver research, showing that alcohol itself is the primary cause for the higher prevalence of liver disease seen in alcoholic patients and not dietary deficiencies and malnutrition that often accompany alcoholi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Institute on Alcohol Abuse and Alcoholism
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860520/ https://www.ncbi.nlm.nih.gov/pubmed/23579939 |
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author | Szabo, Gyongyi Mandrekar, Pranoti |
author_facet | Szabo, Gyongyi Mandrekar, Pranoti |
author_sort | Szabo, Gyongyi |
collection | PubMed |
description | Thirty-five years ago Charles Lieber and colleagues (1975) published a seminal article in liver research, showing that alcohol itself is the primary cause for the higher prevalence of liver disease seen in alcoholic patients and not dietary deficiencies and malnutrition that often accompany alcoholism. Their groundbreaking research dispelled previously held theories that alcohol was not a major cause of liver damage and led to several decades of study of the deleterious effects of alcohol and its metabolism on the liver. Since that early study, clinical and experimental studies have continued to show a firm connection between high amounts of alcohol consumption and liver disease. This article tracks advances in alcohol-related liver disease research over the past 40 years and describes how these discoveries are helping scientists to gain insight into therapeutic targets that may help to combat this life-threatening disease. |
format | Online Article Text |
id | pubmed-3860520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | National Institute on Alcohol Abuse and Alcoholism |
record_format | MEDLINE/PubMed |
spelling | pubmed-38605202014-01-06 Focus On: Alcohol and the Liver Szabo, Gyongyi Mandrekar, Pranoti Alcohol Res Health Alcohol and Health Thirty-five years ago Charles Lieber and colleagues (1975) published a seminal article in liver research, showing that alcohol itself is the primary cause for the higher prevalence of liver disease seen in alcoholic patients and not dietary deficiencies and malnutrition that often accompany alcoholism. Their groundbreaking research dispelled previously held theories that alcohol was not a major cause of liver damage and led to several decades of study of the deleterious effects of alcohol and its metabolism on the liver. Since that early study, clinical and experimental studies have continued to show a firm connection between high amounts of alcohol consumption and liver disease. This article tracks advances in alcohol-related liver disease research over the past 40 years and describes how these discoveries are helping scientists to gain insight into therapeutic targets that may help to combat this life-threatening disease. National Institute on Alcohol Abuse and Alcoholism 2010 /pmc/articles/PMC3860520/ /pubmed/23579939 Text en |
spellingShingle | Alcohol and Health Szabo, Gyongyi Mandrekar, Pranoti Focus On: Alcohol and the Liver |
title | Focus On: Alcohol and the Liver |
title_full | Focus On: Alcohol and the Liver |
title_fullStr | Focus On: Alcohol and the Liver |
title_full_unstemmed | Focus On: Alcohol and the Liver |
title_short | Focus On: Alcohol and the Liver |
title_sort | focus on: alcohol and the liver |
topic | Alcohol and Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860520/ https://www.ncbi.nlm.nih.gov/pubmed/23579939 |
work_keys_str_mv | AT szabogyongyi focusonalcoholandtheliver AT mandrekarpranoti focusonalcoholandtheliver |