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Parathyroid-Specific Deletion of Klotho Unravels a Novel Calcineurin-Dependent FGF23 Signaling Pathway That Regulates PTH Secretion

Klotho acts as a co-receptor for and dictates tissue specificity of circulating FGF23. FGF23 inhibits PTH secretion, and reduced Klotho abundance is considered a pathogenic factor in renal secondary hyperparathyroidism. To dissect the role of parathyroid gland resident Klotho in health and disease,...

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Detalles Bibliográficos
Autores principales:	Olauson, Hannes, Lindberg, Karolina, Amin, Risul, Sato, Tadatoshi, Jia, Ting, Goetz, Regina, Mohammadi, Moosa, Andersson, Göran, Lanske, Beate, Larsson, Tobias E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861040/ https://www.ncbi.nlm.nih.gov/pubmed/24348262 http://dx.doi.org/10.1371/journal.pgen.1003975

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