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Activation of serum/glucocorticoid-induced kinase 1 (SGK1) underlies increased glycogen levels, mTOR activation, and autophagy defects in Lafora disease

Lafora disease (LD), a fatal genetic form of myoclonic epilepsy, is characterized by abnormally high levels of cellular glycogen and its accumulation as Lafora bodies in affected tissues. Therefore the two defective proteins in LD—laforin phosphatase and malin ubiquitin ligase—are believed to be inv...

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Detalles Bibliográficos
Autores principales:	Singh, Pankaj Kumar, Singh, Sweta, Ganesh, Subramaniam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861076/ https://www.ncbi.nlm.nih.gov/pubmed/24131995 http://dx.doi.org/10.1091/mbc.E13-05-0261

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