Corticosteroids for Dengue – Why Don't They Work?

BACKGROUND: Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue. FINDINGS: In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in...

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Autores principales: Nguyen, Thi Hanh Tien, Nguyen, Than Ha Quyen, Vu, Tuan Trung, Farrar, Jeremy, Hoang, Truong Long, Dong, Thi Hoai Tam, Ngoc Tran, Van, Phung, Khanh Lam, Wolbers, Marcel, Whitehead, Stephen S., Hibberd, Martin L., Wills, Bridget, Simmons, Cameron P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861232/
https://www.ncbi.nlm.nih.gov/pubmed/24349598
http://dx.doi.org/10.1371/journal.pntd.0002592
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author Nguyen, Thi Hanh Tien
Nguyen, Than Ha Quyen
Vu, Tuan Trung
Farrar, Jeremy
Hoang, Truong Long
Dong, Thi Hoai Tam
Ngoc Tran, Van
Phung, Khanh Lam
Wolbers, Marcel
Whitehead, Stephen S.
Hibberd, Martin L.
Wills, Bridget
Simmons, Cameron P.
author_facet Nguyen, Thi Hanh Tien
Nguyen, Than Ha Quyen
Vu, Tuan Trung
Farrar, Jeremy
Hoang, Truong Long
Dong, Thi Hoai Tam
Ngoc Tran, Van
Phung, Khanh Lam
Wolbers, Marcel
Whitehead, Stephen S.
Hibberd, Martin L.
Wills, Bridget
Simmons, Cameron P.
author_sort Nguyen, Thi Hanh Tien
collection PubMed
description BACKGROUND: Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue. FINDINGS: In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK cell cytolytic functions. Additionally, prednisolone therapy was not associated with changes in plasma cytokine levels. CONCLUSION: The inability of prednisolone treatment to markedly attenuate the host immune response is instructive for planning future therapeutic strategies for dengue.
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spelling pubmed-38612322013-12-17 Corticosteroids for Dengue – Why Don't They Work? Nguyen, Thi Hanh Tien Nguyen, Than Ha Quyen Vu, Tuan Trung Farrar, Jeremy Hoang, Truong Long Dong, Thi Hoai Tam Ngoc Tran, Van Phung, Khanh Lam Wolbers, Marcel Whitehead, Stephen S. Hibberd, Martin L. Wills, Bridget Simmons, Cameron P. PLoS Negl Trop Dis Research Article BACKGROUND: Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue. FINDINGS: In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK cell cytolytic functions. Additionally, prednisolone therapy was not associated with changes in plasma cytokine levels. CONCLUSION: The inability of prednisolone treatment to markedly attenuate the host immune response is instructive for planning future therapeutic strategies for dengue. Public Library of Science 2013-12-12 /pmc/articles/PMC3861232/ /pubmed/24349598 http://dx.doi.org/10.1371/journal.pntd.0002592 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Nguyen, Thi Hanh Tien
Nguyen, Than Ha Quyen
Vu, Tuan Trung
Farrar, Jeremy
Hoang, Truong Long
Dong, Thi Hoai Tam
Ngoc Tran, Van
Phung, Khanh Lam
Wolbers, Marcel
Whitehead, Stephen S.
Hibberd, Martin L.
Wills, Bridget
Simmons, Cameron P.
Corticosteroids for Dengue – Why Don't They Work?
title Corticosteroids for Dengue – Why Don't They Work?
title_full Corticosteroids for Dengue – Why Don't They Work?
title_fullStr Corticosteroids for Dengue – Why Don't They Work?
title_full_unstemmed Corticosteroids for Dengue – Why Don't They Work?
title_short Corticosteroids for Dengue – Why Don't They Work?
title_sort corticosteroids for dengue – why don't they work?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861232/
https://www.ncbi.nlm.nih.gov/pubmed/24349598
http://dx.doi.org/10.1371/journal.pntd.0002592
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