Cargando…

ESAT-6 (EsxA) and TB10.4 (EsxH) Based Vaccines for Pre- and Post-Exposure Tuberculosis Vaccination

The ESX systems from Mycobacterium tuberculosis are responsible for the secretion of highly immunogenic proteins of key importance for bacterial survival and growth. The two prototypic proteins, ESAT-6 (EsxA from ESX-1) and TB10.4 (EsxH from ESX-3) share a lot of characteristics regarding genome org...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hoang, Truc, Aagaard, Claus, Dietrich, Jes, Cassidy, Joseph P., Dolganov, Gregory, Schoolnik, Gary K., Lundberg, Carina Vingsbo, Agger, Else Marie, Andersen, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861245/ https://www.ncbi.nlm.nih.gov/pubmed/24349004 http://dx.doi.org/10.1371/journal.pone.0080579

Ejemplares similares

Assessment of the Genetic Diversity of Mycobacterium tuberculosis esxA, esxH, and fbpB Genes among Clinical Isolates and Its Implication for the Future Immunization by New Tuberculosis Subunit Vaccines Ag85B-ESAT-6 and Ag85B-TB10.4
por: Davila, Jose, et al.
Publicado: (2010)

In silico EsxG EsxH rational epitope selection: Candidate epitopes for vaccine design against pulmonary tuberculosis
por: Martinez-Olivares, Constanza Estefania, et al.
Publicado: (2023)

Post-translational knockdown and post-secretional modification of EsxA determine contribution of EsxA membrane permeabilizing activity for mycobacterial intracellular survival
por: Bao, Yanqing, et al.
Publicado: (2021)

A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response
por: Sutiwisesak, Rujapak, et al.
Publicado: (2020)

Mycobacterium tuberculosis Type VII Secreted Effector EsxH Targets Host ESCRT to Impair Trafficking
por: Mehra, Alka, et al.
Publicado: (2013)

EsxA might as a virulence factor induce antibodies in patients with Staphylococcus aureus infection
por: Zhou, Huiqin, et al.
Publicado: (2013)

Cloning and expression of the EsxA gene and the growth-promoting effects of the encoded protein on rice seedlings
por: Yu, Wen-qing, et al.
Publicado: (2021)

A Small Protein but with Diverse Roles: A Review of EsxA in Mycobacterium–Host Interaction
por: Bao, Yanqing, et al.
Publicado: (2021)

An N-acetyltransferase required for EsxA N-terminal protein acetylation and virulence in Mycobacterium marinum
por: Collars, Owen A., et al.
Publicado: (2023)

The ESX-4 substrates, EsxU and EsxT, modulate Mycobacterium abscessus fitness
por: Lagune, Marion, et al.
Publicado: (2022)

Protein Elicitor EsxA Induces Resistance to Seedling Blight and PR Genes Differential Transcription in Rice
por: Yu, Wen Qing, et al.
Publicado: (2021)

Overexpression of a Mycobacterium ulcerans Ag85B-EsxH Fusion Protein in Recombinant BCG Improves Experimental Buruli Ulcer Vaccine Efficacy
por: Hart, Bryan E., et al.
Publicado: (2016)

Opposing roles of σ(B )and σ(B)-controlled SpoVG in the global regulation of esxA in Staphylococcus aureus
por: Schulthess, Bettina, et al.
Publicado: (2012)

Solution Structure of the Mycobacterium tuberculosis EsxG·EsxH Complex: FUNCTIONAL IMPLICATIONS AND COMPARISONS WITH OTHER M. TUBERCULOSIS Esx FAMILY COMPLEXES
por: Ilghari, Dariush, et al.
Publicado: (2011)

Virtualization with VMware ESX Server
por: Muller, Al
Publicado: (2005)

Mycosins Are Required for the Stabilization of the ESX-1 and ESX-5 Type VII Secretion Membrane Complexes
por: van Winden, Vincent J. C., et al.
Publicado: (2016)

EsxA membrane-permeabilizing activity plays a key role in mycobacterial cytosolic translocation and virulence: effects of single-residue mutations at glutamine 5
por: Zhang, Qi, et al.
Publicado: (2016)

The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence
por: Osman, Morwan M., et al.
Publicado: (2022)

Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions
por: Gey van Pittius, Nicolaas C, et al.
Publicado: (2006)

Introducing the ESAT-6 free IGRA, a companion diagnostic for TB vaccines based on ESAT-6
por: Ruhwald, Morten, et al.
Publicado: (2017)

The ESX-1 Substrate PPE68 Has a Key Function in ESX-1-Mediated Secretion in Mycobacterium marinum
por: Damen, Merel P. M., et al.
Publicado: (2022)

The structure of the endogenous ESX-3 secretion system
por: Poweleit, Nicole, et al.
Publicado: (2019)

Live attenuated Salmonella typhimurium vaccines delivering SaEsxA and SaEsxB via type III secretion system confer protection against Staphylococcus aureus infection
por: Xu, Chen, et al.
Publicado: (2018)

How to cheat at configuring VmWare ESX server
por: Rule, David
Publicado: (2007)

The ESX System in Bacillus subtilis Mediates Protein Secretion
por: Huppert, Laura A., et al.
Publicado: (2014)

ESX secretion system: The gatekeepers of mycobacterial survivability and pathogenesis
por: ROY, SADHANA, et al.
Publicado: (2020)

Development of an In Vitro Membrane Model to Study the Function of EsxAB Heterodimer and Establish the Role of EsxB in Membrane Permeabilizing Activity of Mycobacterium tuberculosis
por: Vazquez Reyes, Salvador, et al.
Publicado: (2020)

Polar Localization of Virulence-Related Esx-1 Secretion in Mycobacteria
por: Carlsson, Fredric, et al.
Publicado: (2009)

VMware ESX and ESXi in the enterprise: planning deployment of virtualization servers
por: Haletky, Edward
Publicado: (2011)

VMware ESX server in the enterprise: planning and securing virtualization servers
por: Haletky, Edward
Publicado: (2008)

ESX-1-induced apoptosis during mycobacterial infection: to be or not to be, that is the question
por: Aguiló, Nacho, et al.
Publicado: (2013)

Modular Organization of the ESX-5 Secretion System in Mycobacterium tuberculosis
por: Shah, Swati, et al.
Publicado: (2016)

Mycobacterial Esx-3 Requires Multiple Components for Iron Acquisition
por: Siegrist, M. Sloan, et al.
Publicado: (2014)

Immunogenicity and Protective Efficacy of a Fusion Protein Tuberculosis Vaccine Combining Five Esx Family Proteins
por: Xiang, Zhi-hao, et al.
Publicado: (2017)

A Novel ESAT-6 Secretion System-Secreted Protein EsxX of Community-Associated Staphylococcus aureus Lineage ST398 Contributes to Immune Evasion and Virulence
por: Dai, Yingxin, et al.
Publicado: (2017)

The plasmid-mediated evolution of the mycobacterial ESX (Type VII) secretion systems
por: Newton-Foot, Mae, et al.
Publicado: (2016)

Pore-forming Esx proteins mediate toxin secretion by Mycobacterium tuberculosis
por: Tak, Uday, et al.
Publicado: (2021)

Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator
por: Abdallah, Abdallah M., et al.
Publicado: (2019)

A Mycobacterium ESX-1–Secreted Virulence Factor with Unique Requirements for Export
por: McLaughlin, Bryant, et al.
Publicado: (2007)

Host-Detrimental Role of Esx-1-Mediated Inflammasome Activation in Mycobacterial Infection
por: Carlsson, Fredric, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_lg7s8jcoe3gvavn865k2ulhnv0