Long Range Linkage Disequilibrium across the Human Genome

Long-range linkage disequilibria (LRLD) between sites that are widely separated on chromosomes may suggest that population admixture, epistatic selection, or other evolutionary forces are at work. We quantified patterns of LRLD on a chromosome-wide level in the YRI population of the HapMap dataset o...

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Detalles Bibliográficos
Autores principales: Koch, Evan, Ristroph, Mickey, Kirkpatrick, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861250/
https://www.ncbi.nlm.nih.gov/pubmed/24349013
http://dx.doi.org/10.1371/journal.pone.0080754
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author Koch, Evan
Ristroph, Mickey
Kirkpatrick, Mark
author_facet Koch, Evan
Ristroph, Mickey
Kirkpatrick, Mark
author_sort Koch, Evan
collection PubMed
description Long-range linkage disequilibria (LRLD) between sites that are widely separated on chromosomes may suggest that population admixture, epistatic selection, or other evolutionary forces are at work. We quantified patterns of LRLD on a chromosome-wide level in the YRI population of the HapMap dataset of single nucleotide polymorphisms (SNPs). We calculated the disequilibrium between all pairs of SNPs on each chromosome (a total of >2×10(11) values) and evaluated significance of overall disequilibrium using randomization. The results show an excess of associations between pairs of distant sites (separated by >0.25 cM) on all of the 22 autosomes. We discuss possible explanations for this observation.
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spelling pubmed-38612502013-12-17 Long Range Linkage Disequilibrium across the Human Genome Koch, Evan Ristroph, Mickey Kirkpatrick, Mark PLoS One Research Article Long-range linkage disequilibria (LRLD) between sites that are widely separated on chromosomes may suggest that population admixture, epistatic selection, or other evolutionary forces are at work. We quantified patterns of LRLD on a chromosome-wide level in the YRI population of the HapMap dataset of single nucleotide polymorphisms (SNPs). We calculated the disequilibrium between all pairs of SNPs on each chromosome (a total of >2×10(11) values) and evaluated significance of overall disequilibrium using randomization. The results show an excess of associations between pairs of distant sites (separated by >0.25 cM) on all of the 22 autosomes. We discuss possible explanations for this observation. Public Library of Science 2013-12-12 /pmc/articles/PMC3861250/ /pubmed/24349013 http://dx.doi.org/10.1371/journal.pone.0080754 Text en © 2013 Koch et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Koch, Evan
Ristroph, Mickey
Kirkpatrick, Mark
Long Range Linkage Disequilibrium across the Human Genome
title Long Range Linkage Disequilibrium across the Human Genome
title_full Long Range Linkage Disequilibrium across the Human Genome
title_fullStr Long Range Linkage Disequilibrium across the Human Genome
title_full_unstemmed Long Range Linkage Disequilibrium across the Human Genome
title_short Long Range Linkage Disequilibrium across the Human Genome
title_sort long range linkage disequilibrium across the human genome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861250/
https://www.ncbi.nlm.nih.gov/pubmed/24349013
http://dx.doi.org/10.1371/journal.pone.0080754
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