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Evaluation of Elevated Mean Pulmonary Arterial Pressure Based on Magnetic Resonance 4D Velocity Mapping: Comparison of Visualization Techniques
PURPOSE: Three-dimensional (3D) magnetic resonance phase contrast imaging (PC-MRI) allows non-invasive diagnosis of pulmonary hypertension (PH) and estimation of elevated mean pulmonary arterial pressure (mPAP) based on vortical motion of blood in the main pulmonary artery. The purpose of the presen...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861394/ https://www.ncbi.nlm.nih.gov/pubmed/24349224 http://dx.doi.org/10.1371/journal.pone.0082212 |
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author | Reiter, Ursula Reiter, Gert Kovacs, Gabor Stalder, Aurelien F. Gulsun, Mehmet A. Greiser, Andreas Olschewski, Horst Fuchsjäger, Michael |
author_facet | Reiter, Ursula Reiter, Gert Kovacs, Gabor Stalder, Aurelien F. Gulsun, Mehmet A. Greiser, Andreas Olschewski, Horst Fuchsjäger, Michael |
author_sort | Reiter, Ursula |
collection | PubMed |
description | PURPOSE: Three-dimensional (3D) magnetic resonance phase contrast imaging (PC-MRI) allows non-invasive diagnosis of pulmonary hypertension (PH) and estimation of elevated mean pulmonary arterial pressure (mPAP) based on vortical motion of blood in the main pulmonary artery. The purpose of the present study was to compare the presence and duration of PH-associated vortices derived from different flow visualization techniques with special respect to their performance for non-invasive assessment of elevated mPAP and diagnosis of PH. METHODS: Fifty patients with suspected PH (23 patients with and 27 without PH) were investigated by right heart catheterization and time-resolved PC-MRI of the main pulmonary artery. PC-MRI data were visualized with dedicated prototype software, providing 3D vector, multi-planar reformatted (MPR) 2D vector, streamline, and particle trace representation of flow patterns. Persistence of PH-associated vortical blood flow (t(vortex)) was evaluated with all visualization techniques. Dependencies of t(vortex) on visualization techniques were analyzed by means of correlation and receiver operating characteristic (ROC) curve analysis. RESULTS: t(vortex) values from 3D vector visualization correlated strongly with those from other visualization techniques (r = 0.98, 0.98 and 0.97 for MPR, streamline and particle trace visualization, respectively). Areas under ROC curves for diagnosis of PH based on t(vortex) did not differ significantly and were 0.998 for 3D vector, MPR vector and particle trace visualization and 0.999 for streamline visualization. Correlations between elevated mPAP and t(vortex) in patients with PH were r = 0.96, 0.93, 0.95 and 0.92 for 3D vector, MPR vector, streamline and particle trace visualization, respectively. Corresponding standard deviations from the linear regression lines ranged between 3 and 4 mmHg. CONCLUSION: 3D vector, MPR vector, streamline as well as particle trace visualization of time-resolved 3D PC-MRI data of the main pulmonary artery can be employed for accurate vortex-based diagnosis of PH and estimation of elevated mPAP. |
format | Online Article Text |
id | pubmed-3861394 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38613942013-12-17 Evaluation of Elevated Mean Pulmonary Arterial Pressure Based on Magnetic Resonance 4D Velocity Mapping: Comparison of Visualization Techniques Reiter, Ursula Reiter, Gert Kovacs, Gabor Stalder, Aurelien F. Gulsun, Mehmet A. Greiser, Andreas Olschewski, Horst Fuchsjäger, Michael PLoS One Research Article PURPOSE: Three-dimensional (3D) magnetic resonance phase contrast imaging (PC-MRI) allows non-invasive diagnosis of pulmonary hypertension (PH) and estimation of elevated mean pulmonary arterial pressure (mPAP) based on vortical motion of blood in the main pulmonary artery. The purpose of the present study was to compare the presence and duration of PH-associated vortices derived from different flow visualization techniques with special respect to their performance for non-invasive assessment of elevated mPAP and diagnosis of PH. METHODS: Fifty patients with suspected PH (23 patients with and 27 without PH) were investigated by right heart catheterization and time-resolved PC-MRI of the main pulmonary artery. PC-MRI data were visualized with dedicated prototype software, providing 3D vector, multi-planar reformatted (MPR) 2D vector, streamline, and particle trace representation of flow patterns. Persistence of PH-associated vortical blood flow (t(vortex)) was evaluated with all visualization techniques. Dependencies of t(vortex) on visualization techniques were analyzed by means of correlation and receiver operating characteristic (ROC) curve analysis. RESULTS: t(vortex) values from 3D vector visualization correlated strongly with those from other visualization techniques (r = 0.98, 0.98 and 0.97 for MPR, streamline and particle trace visualization, respectively). Areas under ROC curves for diagnosis of PH based on t(vortex) did not differ significantly and were 0.998 for 3D vector, MPR vector and particle trace visualization and 0.999 for streamline visualization. Correlations between elevated mPAP and t(vortex) in patients with PH were r = 0.96, 0.93, 0.95 and 0.92 for 3D vector, MPR vector, streamline and particle trace visualization, respectively. Corresponding standard deviations from the linear regression lines ranged between 3 and 4 mmHg. CONCLUSION: 3D vector, MPR vector, streamline as well as particle trace visualization of time-resolved 3D PC-MRI data of the main pulmonary artery can be employed for accurate vortex-based diagnosis of PH and estimation of elevated mPAP. Public Library of Science 2013-12-12 /pmc/articles/PMC3861394/ /pubmed/24349224 http://dx.doi.org/10.1371/journal.pone.0082212 Text en © 2013 Reiter et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Reiter, Ursula Reiter, Gert Kovacs, Gabor Stalder, Aurelien F. Gulsun, Mehmet A. Greiser, Andreas Olschewski, Horst Fuchsjäger, Michael Evaluation of Elevated Mean Pulmonary Arterial Pressure Based on Magnetic Resonance 4D Velocity Mapping: Comparison of Visualization Techniques |
title | Evaluation of Elevated Mean Pulmonary Arterial Pressure Based on Magnetic Resonance 4D Velocity Mapping: Comparison of Visualization Techniques |
title_full | Evaluation of Elevated Mean Pulmonary Arterial Pressure Based on Magnetic Resonance 4D Velocity Mapping: Comparison of Visualization Techniques |
title_fullStr | Evaluation of Elevated Mean Pulmonary Arterial Pressure Based on Magnetic Resonance 4D Velocity Mapping: Comparison of Visualization Techniques |
title_full_unstemmed | Evaluation of Elevated Mean Pulmonary Arterial Pressure Based on Magnetic Resonance 4D Velocity Mapping: Comparison of Visualization Techniques |
title_short | Evaluation of Elevated Mean Pulmonary Arterial Pressure Based on Magnetic Resonance 4D Velocity Mapping: Comparison of Visualization Techniques |
title_sort | evaluation of elevated mean pulmonary arterial pressure based on magnetic resonance 4d velocity mapping: comparison of visualization techniques |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861394/ https://www.ncbi.nlm.nih.gov/pubmed/24349224 http://dx.doi.org/10.1371/journal.pone.0082212 |
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