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The TGFB1 Functional Polymorphism rs1800469 and Susceptibility to Atrial Fibrillation in Two Chinese Han Populations
Transforming growth factor-β1 (TGF-β1) is related to the degree of atrial fibrosis and plays critical roles in the induction and perpetuation of atrial fibrillation (AF). To investigate the association of the common promoter polymorphism rs1800469 in the TGF-β1 gene (TGFB1) with the risk of AF in Ch...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861462/ https://www.ncbi.nlm.nih.gov/pubmed/24349426 http://dx.doi.org/10.1371/journal.pone.0083033 |
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author | Zheng, Weixing Yan, Chenghui Wang, Xiaohu Luo, Zhurong Chen, Fengping Yang, Yuhui Liu, Donglin Gai, Xiaobo Hou, Jianping Huang, Mingfang |
author_facet | Zheng, Weixing Yan, Chenghui Wang, Xiaohu Luo, Zhurong Chen, Fengping Yang, Yuhui Liu, Donglin Gai, Xiaobo Hou, Jianping Huang, Mingfang |
author_sort | Zheng, Weixing |
collection | PubMed |
description | Transforming growth factor-β1 (TGF-β1) is related to the degree of atrial fibrosis and plays critical roles in the induction and perpetuation of atrial fibrillation (AF). To investigate the association of the common promoter polymorphism rs1800469 in the TGF-β1 gene (TGFB1) with the risk of AF in Chinese Han population, we carried out a case-control study of two hospital-based independent populations: Southeast Chinese population (581 patients with AF and 723 controls), and Northeast Chinese population (308 AF patients and 292 controls). Two hundred and seventy-eight cases of AF were lone AF and 334 cases of AF were diagnosed as paroxysmal AF. In both populations, AF patients had larger left atrial diameters than the controls did. The rs1800469 genotypes in the TGFB1 gene were determined by polymerase chain reaction-restriction fragment length polymorphism. The genotype and allele frequencies of rs1800469 were not different between AF patients and controls of the Southeast Chinese population, Northeast Chinese population, and total Study Population. After adjustment for age, sex, hypertension and LAD, there was no association between the rs1800469 polymorphism and the risk of AF under the dominant, recessive and additive genetic models. Similar results were obtained from subanalysis of the lone and paroxymal AF subgroups. Our results do not support the role of the TGFB1 rs1800469 functional gene variant in the development of AF in the Chinese Han population. |
format | Online Article Text |
id | pubmed-3861462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38614622013-12-17 The TGFB1 Functional Polymorphism rs1800469 and Susceptibility to Atrial Fibrillation in Two Chinese Han Populations Zheng, Weixing Yan, Chenghui Wang, Xiaohu Luo, Zhurong Chen, Fengping Yang, Yuhui Liu, Donglin Gai, Xiaobo Hou, Jianping Huang, Mingfang PLoS One Research Article Transforming growth factor-β1 (TGF-β1) is related to the degree of atrial fibrosis and plays critical roles in the induction and perpetuation of atrial fibrillation (AF). To investigate the association of the common promoter polymorphism rs1800469 in the TGF-β1 gene (TGFB1) with the risk of AF in Chinese Han population, we carried out a case-control study of two hospital-based independent populations: Southeast Chinese population (581 patients with AF and 723 controls), and Northeast Chinese population (308 AF patients and 292 controls). Two hundred and seventy-eight cases of AF were lone AF and 334 cases of AF were diagnosed as paroxysmal AF. In both populations, AF patients had larger left atrial diameters than the controls did. The rs1800469 genotypes in the TGFB1 gene were determined by polymerase chain reaction-restriction fragment length polymorphism. The genotype and allele frequencies of rs1800469 were not different between AF patients and controls of the Southeast Chinese population, Northeast Chinese population, and total Study Population. After adjustment for age, sex, hypertension and LAD, there was no association between the rs1800469 polymorphism and the risk of AF under the dominant, recessive and additive genetic models. Similar results were obtained from subanalysis of the lone and paroxymal AF subgroups. Our results do not support the role of the TGFB1 rs1800469 functional gene variant in the development of AF in the Chinese Han population. Public Library of Science 2013-12-12 /pmc/articles/PMC3861462/ /pubmed/24349426 http://dx.doi.org/10.1371/journal.pone.0083033 Text en © 2013 Zheng et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Zheng, Weixing Yan, Chenghui Wang, Xiaohu Luo, Zhurong Chen, Fengping Yang, Yuhui Liu, Donglin Gai, Xiaobo Hou, Jianping Huang, Mingfang The TGFB1 Functional Polymorphism rs1800469 and Susceptibility to Atrial Fibrillation in Two Chinese Han Populations |
title | The TGFB1 Functional Polymorphism rs1800469 and Susceptibility to Atrial Fibrillation in Two Chinese Han Populations |
title_full | The TGFB1 Functional Polymorphism rs1800469 and Susceptibility to Atrial Fibrillation in Two Chinese Han Populations |
title_fullStr | The TGFB1 Functional Polymorphism rs1800469 and Susceptibility to Atrial Fibrillation in Two Chinese Han Populations |
title_full_unstemmed | The TGFB1 Functional Polymorphism rs1800469 and Susceptibility to Atrial Fibrillation in Two Chinese Han Populations |
title_short | The TGFB1 Functional Polymorphism rs1800469 and Susceptibility to Atrial Fibrillation in Two Chinese Han Populations |
title_sort | tgfb1 functional polymorphism rs1800469 and susceptibility to atrial fibrillation in two chinese han populations |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861462/ https://www.ncbi.nlm.nih.gov/pubmed/24349426 http://dx.doi.org/10.1371/journal.pone.0083033 |
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