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Identification of Putative Target Genes of the Transcription Factor RUNX2
Comparisons of the genomes of Neandertals and Denisovans with present-day human genomes have suggested that the gene RUNX2, which encodes a transcription factor, may have been positively selected during early human evolution. Here, we overexpress RUNX2 in ten human cell lines and identify genes that...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861491/ https://www.ncbi.nlm.nih.gov/pubmed/24349465 http://dx.doi.org/10.1371/journal.pone.0083218 |
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author | Kuhlwilm, Martin Davierwala, Armaity Pääbo, Svante |
author_facet | Kuhlwilm, Martin Davierwala, Armaity Pääbo, Svante |
author_sort | Kuhlwilm, Martin |
collection | PubMed |
description | Comparisons of the genomes of Neandertals and Denisovans with present-day human genomes have suggested that the gene RUNX2, which encodes a transcription factor, may have been positively selected during early human evolution. Here, we overexpress RUNX2 in ten human cell lines and identify genes that are directly or indirectly affected by RUNX2 expression. We find a number of genes not previously known to be affected by RUNX2 expression, in particular BIRC3, genes encoded on the mitochondrial genome, and several genes involved in bone and tooth formation. These genes are likely to provide inroads into pathways affected by RUNX2 and potentially by the evolutionary changes that affected RUNX2 in modern humans. |
format | Online Article Text |
id | pubmed-3861491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-38614912013-12-17 Identification of Putative Target Genes of the Transcription Factor RUNX2 Kuhlwilm, Martin Davierwala, Armaity Pääbo, Svante PLoS One Research Article Comparisons of the genomes of Neandertals and Denisovans with present-day human genomes have suggested that the gene RUNX2, which encodes a transcription factor, may have been positively selected during early human evolution. Here, we overexpress RUNX2 in ten human cell lines and identify genes that are directly or indirectly affected by RUNX2 expression. We find a number of genes not previously known to be affected by RUNX2 expression, in particular BIRC3, genes encoded on the mitochondrial genome, and several genes involved in bone and tooth formation. These genes are likely to provide inroads into pathways affected by RUNX2 and potentially by the evolutionary changes that affected RUNX2 in modern humans. Public Library of Science 2013-12-12 /pmc/articles/PMC3861491/ /pubmed/24349465 http://dx.doi.org/10.1371/journal.pone.0083218 Text en © 2013 Kuhlwilm et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Kuhlwilm, Martin Davierwala, Armaity Pääbo, Svante Identification of Putative Target Genes of the Transcription Factor RUNX2 |
title | Identification of Putative Target Genes of the Transcription Factor RUNX2
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title_full | Identification of Putative Target Genes of the Transcription Factor RUNX2
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title_fullStr | Identification of Putative Target Genes of the Transcription Factor RUNX2
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title_full_unstemmed | Identification of Putative Target Genes of the Transcription Factor RUNX2
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title_short | Identification of Putative Target Genes of the Transcription Factor RUNX2
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title_sort | identification of putative target genes of the transcription factor runx2 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861491/ https://www.ncbi.nlm.nih.gov/pubmed/24349465 http://dx.doi.org/10.1371/journal.pone.0083218 |
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