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Significance of thymidylate synthase expression for resistance to pemetrexed in pulmonary adenocarcinoma
Pemetrexed (PEM), a multi-targeted antifolate, has promising clinical activity in non-squamous non-small cell lung cancer. However, the majority of patients eventually acquire resistance to PEM. To evaluate the resistant mechanisms, the A549 lung adenocarcinoma cell line was exposed to stepwise incr...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
D.A. Spandidos
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861605/ https://www.ncbi.nlm.nih.gov/pubmed/24348854 http://dx.doi.org/10.3892/ol.2013.1688 |