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Significance of thymidylate synthase expression for resistance to pemetrexed in pulmonary adenocarcinoma

Pemetrexed (PEM), a multi-targeted antifolate, has promising clinical activity in non-squamous non-small cell lung cancer. However, the majority of patients eventually acquire resistance to PEM. To evaluate the resistant mechanisms, the A549 lung adenocarcinoma cell line was exposed to stepwise incr...

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Detalles Bibliográficos
Autores principales:	YANG, MIN, FAN, WEI-FEI, PU, XIAO-LIN, LIU, FU-YIN, MENG, LI-JUAN, WANG, JUN
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861605/ https://www.ncbi.nlm.nih.gov/pubmed/24348854 http://dx.doi.org/10.3892/ol.2013.1688

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