Functional Consequences of Complementarity-determining Region Deactivation in a Multifunctional Anti-nucleic Acid Antibody

Many murine monoclonal anti-DNA antibodies (Abs) derived from mice models for systemic lupus erythematosus have additional cell-penetration and/or nucleic acid-hydrolysis properties. Here, we examined the influence of deactivating each complementarity-determining region (CDR) within a multifunctiona...

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Detalles Bibliográficos
Autores principales: Lee, Jiyeon, Kim, Hye-Jin, Roh, Jooho, Seo, Youngsil, Kim, Minjae, Jun, Hye-Ryeong, Pham, Chuong D., Kwon, Myung-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861637/
https://www.ncbi.nlm.nih.gov/pubmed/24155236
http://dx.doi.org/10.1074/jbc.M113.508499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861637/
https://www.ncbi.nlm.nih.gov/pubmed/24155236
http://dx.doi.org/10.1074/jbc.M113.508499

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