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Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements

Recent genome sequencing studies have identified several classes of complex genomic rearrangements that appear to be derived from a single catastrophic event. These discoveries identify ways that genomes can be altered in single large jumps rather than by many incremental steps. Here we compare and...

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Detalles Bibliográficos
Autores principales: Zhang, Cheng-Zhong, Leibowitz, Mitchell L., Pellman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861665/
https://www.ncbi.nlm.nih.gov/pubmed/24298051
http://dx.doi.org/10.1101/gad.229559.113
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author Zhang, Cheng-Zhong
Leibowitz, Mitchell L.
Pellman, David
author_facet Zhang, Cheng-Zhong
Leibowitz, Mitchell L.
Pellman, David
author_sort Zhang, Cheng-Zhong
collection PubMed
description Recent genome sequencing studies have identified several classes of complex genomic rearrangements that appear to be derived from a single catastrophic event. These discoveries identify ways that genomes can be altered in single large jumps rather than by many incremental steps. Here we compare and contrast these phenomena and examine the evidence that they arise “all at once.” We consider the impact of massive chromosomal change for the development of diseases such as cancer and for evolution more generally. Finally, we summarize current models for underlying mechanisms and discuss strategies for testing these models.
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spelling pubmed-38616652014-06-01 Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements Zhang, Cheng-Zhong Leibowitz, Mitchell L. Pellman, David Genes Dev Review Recent genome sequencing studies have identified several classes of complex genomic rearrangements that appear to be derived from a single catastrophic event. These discoveries identify ways that genomes can be altered in single large jumps rather than by many incremental steps. Here we compare and contrast these phenomena and examine the evidence that they arise “all at once.” We consider the impact of massive chromosomal change for the development of diseases such as cancer and for evolution more generally. Finally, we summarize current models for underlying mechanisms and discuss strategies for testing these models. Cold Spring Harbor Laboratory Press 2013-12-01 /pmc/articles/PMC3861665/ /pubmed/24298051 http://dx.doi.org/10.1101/gad.229559.113 Text en © 2013 Zhang et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.
spellingShingle Review
Zhang, Cheng-Zhong
Leibowitz, Mitchell L.
Pellman, David
Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements
title Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements
title_full Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements
title_fullStr Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements
title_full_unstemmed Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements
title_short Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements
title_sort chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861665/
https://www.ncbi.nlm.nih.gov/pubmed/24298051
http://dx.doi.org/10.1101/gad.229559.113
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