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Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements
Recent genome sequencing studies have identified several classes of complex genomic rearrangements that appear to be derived from a single catastrophic event. These discoveries identify ways that genomes can be altered in single large jumps rather than by many incremental steps. Here we compare and...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861665/ https://www.ncbi.nlm.nih.gov/pubmed/24298051 http://dx.doi.org/10.1101/gad.229559.113 |
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author | Zhang, Cheng-Zhong Leibowitz, Mitchell L. Pellman, David |
author_facet | Zhang, Cheng-Zhong Leibowitz, Mitchell L. Pellman, David |
author_sort | Zhang, Cheng-Zhong |
collection | PubMed |
description | Recent genome sequencing studies have identified several classes of complex genomic rearrangements that appear to be derived from a single catastrophic event. These discoveries identify ways that genomes can be altered in single large jumps rather than by many incremental steps. Here we compare and contrast these phenomena and examine the evidence that they arise “all at once.” We consider the impact of massive chromosomal change for the development of diseases such as cancer and for evolution more generally. Finally, we summarize current models for underlying mechanisms and discuss strategies for testing these models. |
format | Online Article Text |
id | pubmed-3861665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-38616652014-06-01 Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements Zhang, Cheng-Zhong Leibowitz, Mitchell L. Pellman, David Genes Dev Review Recent genome sequencing studies have identified several classes of complex genomic rearrangements that appear to be derived from a single catastrophic event. These discoveries identify ways that genomes can be altered in single large jumps rather than by many incremental steps. Here we compare and contrast these phenomena and examine the evidence that they arise “all at once.” We consider the impact of massive chromosomal change for the development of diseases such as cancer and for evolution more generally. Finally, we summarize current models for underlying mechanisms and discuss strategies for testing these models. Cold Spring Harbor Laboratory Press 2013-12-01 /pmc/articles/PMC3861665/ /pubmed/24298051 http://dx.doi.org/10.1101/gad.229559.113 Text en © 2013 Zhang et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/. |
spellingShingle | Review Zhang, Cheng-Zhong Leibowitz, Mitchell L. Pellman, David Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements |
title | Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements |
title_full | Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements |
title_fullStr | Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements |
title_full_unstemmed | Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements |
title_short | Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements |
title_sort | chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861665/ https://www.ncbi.nlm.nih.gov/pubmed/24298051 http://dx.doi.org/10.1101/gad.229559.113 |
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