Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template

Deregulated origin licensing and rereplication promote genome instability and tumorigenesis by largely elusive mechanisms. Investigating the consequences of Early mitotic inhibitor 1 (Emi1) depletion in human cells, previously associated with rereplication, we show by DNA fiber labeling that origin...

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Detalles Bibliográficos
Autores principales: Neelsen, Kai J., Zanini, Isabella M.Y., Mijic, Sofija, Herrador, Raquel, Zellweger, Ralph, Ray Chaudhuri, Arnab, Creavin, Kevin D., Blow, J. Julian, Lopes, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861667/
https://www.ncbi.nlm.nih.gov/pubmed/24298053
http://dx.doi.org/10.1101/gad.226373.113

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